1245537-68-1 Usage
Description
1-(3-(Trifluoromethyl)-4-(piperazin-1-yl)phenyl)-8-(6-methoxypyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one maleic acid salt, also known as BGT 226, is a novel dual inhibitor of phosphatidyl inositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). It has been shown to be effective in combination with gefitinib, an epidermal growth factor receptor (EGFR) inhibitor, for the treatment of EGFR inhibitor-sensitive non-small cell lung cancer (NSCLC).
Uses
Used in Oncology:
BGT 226 is used as a dual PI3K/mTOR inhibitor for the treatment of EGFR inhibitor-sensitive non-small cell lung cancer (NSCLC). It has been shown to be effective in combination with gefitinib, enhancing the therapeutic efficacy and overcoming resistance to EGFR-targeted therapies.
Used in Drug Development:
BGT 226 is also used in the development of novel targeted therapies for cancer treatment. Its dual inhibition of PI3K and mTOR pathways makes it a promising candidate for the treatment of various malignancies, particularly those with alterations in these pathways. Further research and clinical trials are needed to explore its potential in other cancer types and therapeutic combinations.
Check Digit Verification of cas no
The CAS Registry Mumber 1245537-68-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,5,3 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1245537-68:
(9*1)+(8*2)+(7*4)+(6*5)+(5*5)+(4*3)+(3*7)+(2*6)+(1*8)=161
161 % 10 = 1
So 1245537-68-1 is a valid CAS Registry Number.
