1245819-33-3

Basic information

• Product Name: (R)-1-chloro-4-(2-nitro-1-phenylethyl)benzene
• Synonyms: (R)-1-chloro-4-(2-nitro-1-phenylethyl)benzene
• CAS NO: 1245819-33-3
• Molecular Weight: 261.708
• Mol File: 1245819-33-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (R)-1-chloro-4-(2-nitro-1-phenylethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-chloro-4-(2-nitro-1-phenylethyl)benzene(1245819-33-3)
• EPA Substance Registry System: (R)-1-chloro-4-(2-nitro-1-phenylethyl)benzene(1245819-33-3)

Safety Data

• Hazardous Substances Data: 1245819-33-3(Hazardous Substances Data)

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 98-80-6 phenylboronic acid 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 

Relevant articles and documents

Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance

Multifunctional isoquinoline-oxazolines (MIQOXs) were conceived and synthesized from commercially available chiral amino acids. The multifunctional role of MIQOXs was demonstrated by Pd-catalyzed highly enantioselective addition of arylboronic acids to nitrostyrenes, and by the discovery of novel antifungal candidates.

Rhodium-catalyzed Asymmetric Arylation of Nitroalkenes Powered by Simple Chiral Sulfur-Olefin Ligands

An efficient rhodium-catalyzed enantioselective addition of potassium organotrifluoroborates to nitroalkenes powered by simple chiral sulfur-olefin ligands is reported. This protocol is applicable to a broad range of 2-aryl-, alkyl-, and heteroaryl-substituted nitroalkenes, allowing access to diverse chiral β,β-disubstituted nitroethanes in good to excellent yields with high enantioselectivity under mild conditions.

A nordehydroabietyl amide-containing chiral diene for rhodium-catalysed asymmetric arylation to nitroolefins

A highly enantioselective rhodium catalysed asymmetric arylation (RCAA) of nitroolefins with arylboronic acids is presented using a newly developed, C1-symmetric, non-covalent interacted, phellandrene derived, nordehydroabietyl amide-containing chiral diene under mild conditions. Stereoelectronic effects were studied, suggesting an activation of the bound substrate through the secondary amide as a hydrogen-bond donor.