1245935-40-3

Basic information

• Product Name: (S)-BendrofluMethiazide
• Synonyms: (S)-BendrofluMethiazide;(3S)-3,4-Dihydro-3-(phenylMethyl)-6-(trifluoroMethyl)-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide
• CAS NO: 1245935-40-3
• Molecular Formula: C₁₅H₁₄F₃N₃O₄S₂
• Molecular Weight: 421.4145696
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 1245935-40-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-BendrofluMethiazide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-BendrofluMethiazide(1245935-40-3)
• EPA Substance Registry System: (S)-BendrofluMethiazide(1245935-40-3)

Safety Data

• Hazardous Substances Data: 1245935-40-3(Hazardous Substances Data)

Usage

Uses

The S-enatiomer of the diuretic Bendroflumethiazide (B133500).

Upstream product

• 73-48-3 bendroflumethiazide 

Relevant articles and documents

Enantioselective potential of polysaccharide-based chiral stationary phases in supercritical fluid chromatography

The enantioselective potential of two polysaccharide-based chiral stationary phases for analysis of chiral structurally diverse biologically active compounds was evaluated in supercritical fluid chromatography using a set of 52 analytes. The chiral selectors immobilized on 2.5?μm silica particles were tris-(3,5-dimethylphenylcarmabate) derivatives of cellulose or amylose. The influence of the polysaccharide backbone, different organic modifiers, and different mobile phase additives on retention and enantioseparation was monitored. Conditions for fast baseline enantioseparation were found for the majority of the compounds. The success rate of baseline and partial enantioseparation with cellulose-based chiral stationary phase was 51.9% and 15.4%, respectively. Using amylose-based chiral stationary phase we obtained 76.9% of baseline enantioseparations and 9.6% of partial enantioseparations of the tested compounds. The best results on cellulose-based chiral stationary phase were achieved particularly with propane-2-ol and a mixture of isopropylamine and trifluoroacetic acid as organic modifier and additive to CO2, respectively. Methanol and basic additive isopropylamine were preferred on amylose-based chiral stationary phase. The complementary enantioselectivity of the cellulose- and amylose-based chiral stationary phases allows separation of the majority of the tested structurally different compounds. Separation systems were found to be directly applicable for analyses of biologically active compounds of interest.

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.