1246560-33-7 Usage
Description
VS-5584 is a purine analog that acts as a potent inhibitor of the Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathways, which play a crucial role in cell proliferation, differentiation, and apoptosis. It exhibits high selectivity with an IC50 of 37 nM for mTOR and IC50s ranging from 16 to 68 nM for the different PI3K isoforms, without significant activity against over 400 additional lipid and protein kinases. By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 shows broad anti-proliferative sensitivity and effectively inhibits tumor growth in human tumor models.
Uses
Used in Oncology:
VS-5584 is used as an anti-cancer agent for its ability to inhibit the PI3K and mTOR pathways, which are often dysregulated in various types of cancer. Its high selectivity and potency make it a promising therapeutic option for treating cancer by reducing cell proliferation and inducing apoptosis.
Used in Drug Development:
In the pharmaceutical industry, VS-5584 serves as a valuable compound for the development of targeted cancer therapies. Its unique mechanism of action and selectivity profile can be leveraged to create more effective and safer treatments for patients with cancer driven by the PI3K and mTOR pathways.
Used in Research:
VS-5584 is also utilized as a research tool in the study of the PI3K and mTOR signaling pathways, helping scientists to better understand the molecular mechanisms underlying cancer development and progression. This knowledge can contribute to the discovery of new therapeutic targets and the improvement of existing cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 1246560-33-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,5,6 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1246560-33:
(9*1)+(8*2)+(7*4)+(6*6)+(5*5)+(4*6)+(3*0)+(2*3)+(1*3)=147
147 % 10 = 7
So 1246560-33-7 is a valid CAS Registry Number.
1246560-33-7Relevant articles and documents
As an inhibitor pyrimidinecarboxylic substd. hydroxyaminopurine compd. serinekinase
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Paragraph 0082, (2016/12/16)
PROBLEM TO BE SOLVED: To provide a pyrimidine substituted purine compound which can be used as a kinase inhibitor in a treatment of serine/threonine protein kinase related disorders/conditions, for example cancer, pre-cancer conditions or hyperplasia, autoimmune or inflammatory diseases or diseases caused by excessive angiogenesis.SOLUTION: There are provided 5-(9-isopropyl-8-methyl-2-morpholine-4-yl-9H-purine-6-yl)-pyrimidine-2-yl amine, preparation method thereof, and pharmaceutical compositions containing the compound.
PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
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Page/Page column 21, (2010/11/03)
The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure (I) or a pharmaceutically acceptable salt thereof
