125013-61-8Relevant articles and documents
Intramolecular Cyclization of 1-(3-Bromopropyl)uracils
Dezor-Mazur, Maria,Koraniak, Henryk,Langer, Jerzy J.,Golankiewicz, Krzysztof
, p. 1209 - 1212 (2007/10/02)
The intramolecular O-alkylation of 1-(3-bromopropyl)uracils proceeds smoothly in basic conditions and yields cyclic ethers as the major products.This reaction competes with the intermolecular N-alkylation of uracil and its derivatives.The mechanism of this reaction is also discussed in terms of reactivity indices calculated using the HMO method.