1253934-12-1

Basic information

• Product Name: 2-[1-(3-hydroxy-3-methylhexanoyloxy)-4-methyl-3-pentenyl]naphthazarin
• Synonyms: 2-[1-(3-hydroxy-3-methylhexanoyloxy)-4-methyl-3-pentenyl]naphthazarin
• CAS NO: 1253934-12-1
• Molecular Weight: 416.471
• Mol File: 1253934-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[1-(3-hydroxy-3-methylhexanoyloxy)-4-methyl-3-pentenyl]naphthazarin(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(3-hydroxy-3-methylhexanoyloxy)-4-methyl-3-pentenyl]naphthazarin(1253934-12-1)
• EPA Substance Registry System: 2-[1-(3-hydroxy-3-methylhexanoyloxy)-4-methyl-3-pentenyl]naphthazarin(1253934-12-1)

Safety Data

• Hazardous Substances Data: 1253934-12-1(Hazardous Substances Data)

Upstream product

• 58888-76-9 3-hydroxy-3-methyl-hexanoic acid 
• 517-89-5 shikonin 

Relevant articles and documents

Synthesis and antitumour activity of β-hydroxyisovalerylshikonin analogues

A series of novel β-hydroxyisovalerylshikonin analogues bearing oxygen-containing substituents at the side-chain hydroxyl of shikonin were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against multi-drug resistant (MDR) cell lines DU-145 and HeLa. Most compounds exhibited significant inhibitory activity on both cell lines. The structure-activity relationship showed the analogues with ether substituents displayed the most potent antitumour activity and selective cytotoxicity towards DU-145. Among the compounds with ether substituents, increasing the steric hindrance in the carbon bearing β-hydroxyl or replace the β-hydroxyl with acetoxy or methoxy would lead to the decline of cytotoxicity.