1254943-75-3

Basic information

• Product Name: C₁₅H₁₂F₃N₃O₃
• CAS NO: 1254943-75-3
• Molecular Weight: 339.274
• Mol File: 1254943-75-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₂F₃N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₂F₃N₃O₃(1254943-75-3)
• EPA Substance Registry System: C₁₅H₁₂F₃N₃O₃(1254943-75-3)

Safety Data

• Hazardous Substances Data: 1254943-75-3(Hazardous Substances Data)

Upstream product

• 400-76-0 4-amino-3-(trifluoromethyl)benzoic acid 
• 119-32-4 4-Methyl-3-nitroanilin 

Downstream Products

• 1254943-87-7 C₁₅H₁₄F₃N₃O 

Relevant articles and documents

Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line

The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 μM) and good selectivity over HS27 fibroblast cell line.