1256490-52-4Relevant articles and documents
Design, synthesis and evaluation of 2′-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents
Cao, Ruiyuan,Fan, Shiyong,Li, Song,Li, Wei,Li, Xiaoyuan,Li, Yuexiang,Yan, Linjie,Zhang, Hongjie,Zhong, Wu
supporting information, (2021/09/28)
A series of phosphoamidate derivatives of nucleoside 2′-acetylene-7-deaza-adenosine (NITD008) were synthesized and evaluated for their in vitro antiviral activities against the enteroviruses EV71 and EV-D68. The phosphoamidate (15f) containing a hexyl est
Nucleotide derivative and pharmaceutical composition and application thereof
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Paragraph 0165-0170, (2021/08/25)
The invention discloses a nucleotide derivative and a pharmaceutical composition and application thereof, wherein the nucleotide derivative is as shown in a formula (I). The compound can be used for preparing anti-virus infection drugs.
Preparation method for phosphamide compound used for synthesis chiral drug
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Paragraph 0032-0034, (2020/05/29)
The invention provides a preparation method for a phosphamide compound used for synthesis of a chiral drug. According to the invention, a compound II with high yield and high purity can be prepared byadopting a NaHCO3 aqueous solution with a specific pH value and a specific volume-to-mass ratio as a solvent for pulping and controlling a temperature and a stirring speed during pulping. By adoptionof a reaction system provided by the invention, an organic solvent is not needed; the discharge of a large amount of an organic solvent waste liquid is reduced; and the process is environmentally-friendly, green and pollution-free.