1257412-02-4

Basic information

• Product Name: C₁₀H₆ClF₃N₂O
• CAS NO: 1257412-02-4
• Molecular Weight: 262.619
• Mol File: 1257412-02-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₆ClF₃N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₆ClF₃N₂O(1257412-02-4)
• EPA Substance Registry System: C₁₀H₆ClF₃N₂O(1257412-02-4)

Safety Data

• Hazardous Substances Data: 1257412-02-4(Hazardous Substances Data)

Upstream product

• 2312-23-4 m-chlorophenylhydrazine hydrochloride 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 1257412-15-9 C₂₅H₁₇ClF₄N₂O₃ 

Relevant articles and documents

Development of the next generation of HIV-1 integrase inhibitors: Pyrazolone as a novel inhibitor scaffold

HIV-1 integrase (IN), one of the essential enzymes in HIV infection, has been validated as a target for HIV treatment. While more than 20 drugs have been approved by the FDA to treat HIV/AIDS, only one drug, Raltegravir (1), was approved as an IN inhibitor. The rapid mutation of the virus, which leads to multidrug resistant HIV strains, presents an urgent need to find potent compounds that can serve as second-generation IN inhibitors. The pyrazolone scaffold, predicted by a computational modeling study using GS-9137(2) as a pharmacophoric model, has shown to inhibit the IN catalytic activities in low micromolar range. We have synthesized various analogs based on the pyrazolone scaffold and performed SAR studies. This paper will showcase the up-to-date result of this scaffold as a promising HIV-1 IN inhibitor.