1257599-61-3

Basic information

• Product Name: C₁₂H₉ClF₃N₃O
• Synonyms: C₁₂H₉ClF₃N₃O
• CAS NO: 1257599-61-3
• Molecular Weight: 303.671
• Mol File: 1257599-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₉ClF₃N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₉ClF₃N₃O(1257599-61-3)
• EPA Substance Registry System: C₁₂H₉ClF₃N₃O(1257599-61-3)

Safety Data

• Hazardous Substances Data: 1257599-61-3(Hazardous Substances Data)

Upstream product

• 344-00-3 ethyl 2-methyl-4,4,4-trifluoroacetoacetate 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines

A series of new strobilurin-pyrimidine analogs were designed and synthesized based on the structures of our previously discovered antiproliferative compounds I and II. Biological evaluation with two human cancer cell lines (A549 and HL60) showed that most of these compounds possessed moderate to potent antiproliferative activity. Two potent candidates (8f, IC50 = 2.2 nM and 11d, IC50 = 3.4 nM) were identified with nanomolar activity against leukemia cancer cell line HL60 for further development. This activity represents a 1000- to 2500-fold improvement compared to the parent compounds I and II and is 20- to 30-fold better than the chemotherapy drug, doxorubicin. The present work provides strong incentive for further development of these strobilurin-pyrimidine analogs as potential antitumor agents for the treatment of leukemia.