1259224-46-8

Basic information

• Product Name: 6-methyl-2,4-bis(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
• Synonyms: 6-methyl-2,4-bis(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
• CAS NO: 1259224-46-8
• Molecular Weight: 363.373
• Mol File: 1259224-46-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-methyl-2,4-bis(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2,4-bis(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione(1259224-46-8)
• EPA Substance Registry System: 6-methyl-2,4-bis(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione(1259224-46-8)

Safety Data

• Hazardous Substances Data: 1259224-46-8(Hazardous Substances Data)

Upstream product

• 932-53-6 6-azathymine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1259224-52-6 6-methyl-2,4-bis[(4-methylene-5-oxo-2-phenyltetrahydrofuran-2-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione 

Relevant articles and documents

Synthesis and antibacterial evaluation of 6-azapyrimidines with α-methylene-γ-(4-substituted phenyl)-γ-butyrolactone pharmacophores

A series of 6-substituted 2-[(4-methylene-5- oxo-2-(4-substituted phenyl) tetrahydrofuran-2-yl)methyl]-1, 2,4-triazine-3,5(2H,4H)-diones (5, 6) and 2,4-bis[(4-methylene- 5-oxo-2-(4-substituted phenyl) tetrahydrofuran-2-yl) methyl]-1,2,4-triazine-3,5(2H,4H)-diones (9, 10) were designed, synthesized, and evaluated for antibacterial activity against Gram-positive and Gram-negative microorganisms. The synthesis of these compounds involved the Reformatsky-type reaction between ethyl α-(bromomethyl) acrylate and the proper ketones. Among these compounds, 2-[(4-methylene-5-oxo-2-phenyl tetrahydrofuran-2-yl) methyl]- 1,2,4-triazine-3,5(2H,4H)-dione (5a) is the most active compound and shown the selective inhibition activity against Proteus vulgaris. Springer Science+Business Media, LLC 2010.