126-92-1 Usage
Description
Sodium 2-ethylhexyl sulfate is a clear, colorless, slightly viscous liquid that is a solid at room temperature. It is an anionic surfactant with various applications in different industries.
Uses
Used in Detergent Industry:
Sodium 2-ethylhexyl sulfate is used as a surfactant in detergent formulations for its ability to reduce surface tension and improve the solubility of hydrophobic compounds.
Used in Pharmaceutical Industry:
Sodium 2-ethylhexyl sulfate is used as a component in stable aqueous suspension formulations, which helps in the dispersion of insoluble drugs in water.
Used in Polymer Industry:
Sodium 2-ethylhexyl sulfate is used as a surfactant in suspension polymerization, which aids in the formation of polymer particles with uniform size and shape.
Used in Analytical Chemistry:
Sodium 2-ethylhexyl sulfate is used in the analysis of phenolic compounds through microchip-capillary electrophoresis (microchip-CE) with pulsed amperometric detection, enhancing the sensitivity and selectivity of the analysis.
Used in Material Science:
Sodium 2-ethylhexyl sulfate is used as charge balancing anions in the synthesis of organo-layered double hydroxides (organo-LDHs), which are materials with potential applications in catalysis, drug delivery, and environmental remediation.
Air & Water Reactions
Water soluble.
Fire Hazard
Sodium 2-ethylhexyl sulfate is probably nonflammable.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. A skin and eye irritant. A combustible liquid. When heated to decomposition it emits very toxic fumes of SOx and Na2O.
Check Digit Verification of cas no
The CAS Registry Mumber 126-92-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 126-92:
(5*1)+(4*2)+(3*6)+(2*9)+(1*2)=51
51 % 10 = 1
So 126-92-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H18O4S/c1-3-5-6-8(4-2)7-12-13(9,10)11/h8H,3-7H2,1-2H3,(H,9,10,11)/p-1
126-92-1Relevant articles and documents
API ionic liquids: Probing the effect of counterion structure on physical form and lipid solubility
Benameur, Hassan,Ford, Leigh,Nguyen, Tri-Hung,Porter, Christopher J. H.,Scammells, Peter J.,Tay, Erin,Williams, Hywel D.
, p. 12788 - 12799 (2020/04/22)
Lipid based formulations (LBFs) are extensively utilised as an enabling technology in drug delivery. The use of ionic liquids (ILs) or lipophilic salts (LS) in drug delivery has also garnered considerable interest due to unique solubility properties. Conversion of active pharmaceutical ingredients (API) to ILs by pairing with an appropriately lipophilic counterion has been shown to decrease melting point of the salt complex and improve solubility in LBFs. However, the relationship between the structure of the counterion, the physicochemical properties of the resulting salts and solubility in LBFs has not been systematically explored. This study investigates the relationship between alkyl sulfate counterion structure and melting temperature (Tm or Tg) in addition to LBF solubility, utilizing cinnarizine and lumefantrine as model weakly basic APIs. Three series of structurally diverse alkyl sulfate counterions were chosen to probe this relationship. Pairing cinnarizine and lumefantrine with a majority of these alkyl sulfate counterions resulted in a reduction in melting temperature and enhanced solubility in model medium chain and long chain LBFs. The chain length of the alkyl sulfate plays a crucial role in performance, and consistently branched alkyl sulfate counterions perform better than straight chain alkyl sulfate counterions, as predicted. Most interestingly, trends in counterion performance were found to be consistent across two APIs with disparate chemical structures. The findings from this study will facilitate the design of counterions which enhance solubility of ionisable drugs and unlock the potential to develop compounds previously restrained by poor solubility.