1263357-63-6

Basic information

• Product Name: C₁₆H₁₈BrClN₂O₃
• CAS NO: 1263357-63-6
• Molecular Weight: 401.688
• Mol File: 1263357-63-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈BrClN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈BrClN₂O₃(1263357-63-6)
• EPA Substance Registry System: C₁₆H₁₈BrClN₂O₃(1263357-63-6)

Safety Data

• Hazardous Substances Data: 1263357-63-6(Hazardous Substances Data)

Upstream product

• 625-52-5 N-Ethylurea 
• 64622-16-8 2-bromo-6-chlorobenzaldehyde 
• 141-97-9 ethyl acetoacetate 

Relevant articles and documents

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists

The synthesis, biological evaluation, and molecular modeling of new 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides(4), 4-hydroxy-2-oxo-1,2- dihydroquinoline-3-carbohydrazide (6), and some hexahydropyrimido[5,4-c] quinoline-2,5-diones (9) produced earlier by our laboratory, as AChE/BuChE inhibitors, is described. From these analyses compound 4c resulted equipotent regarding the inhibition of cholinesterases'; inhibitors 6k, 9a, 9b were selective for AChE, whereas product 4d proved selective for BuChE. Docking analysis has been carry out in order to identify the binding mode in the active site, and to explain the observed selectivities. Only compound 9a has been shown to decrease K+-induced calcium signals in bovine chromaffin cells.