126759-31-7

Basic information

• Product Name: Benzene, 2-ethenyl-4-methoxy-1-nitro-
• CAS NO: 126759-31-7
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.175
• Mol File: 126759-31-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 2-ethenyl-4-methoxy-1-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2-ethenyl-4-methoxy-1-nitro-(126759-31-7)
• EPA Substance Registry System: Benzene, 2-ethenyl-4-methoxy-1-nitro-(126759-31-7)

Safety Data

• Hazardous Substances Data: 126759-31-7(Hazardous Substances Data)

Upstream product

• 74-85-1 ethene 
• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 
• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 879-55-0 (5-methoxy-2'-nitrophenyl)methanol 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Downstream Products

• 54197-64-7 6-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline 
• 210536-47-3 2-ethenyl-4-methoxybenzenamine 
• 116707-99-4 1,3-dimethyl-5-methoxyindolin-2-one 
• 522613-62-3 (4-methoxy-2-vinylphenyl)carbamic acid tert-butyl ester 
• 1006-94-6 5-methoxylindole 
• 126759-39-5 2-<(6-methoxy-2-nitrophenyl)methyl>-1,3-dioxane 
• 69111-47-3 5-methoxy-2-nitrophenylacetaldehyde 
• 146667-94-9 2,2-dimethoxy-1-(5-methoxy-2-nitrophenyl)ethane 

Relevant articles and documents

Iron-Catalyzed Reductive Cyclization by Hydromagnesiation: A Modular Strategy Towards N-Heterocycles

A reductive cyclization to prepare a variety of N-heterocycles, through the use of ortho-vinylanilides, is reported. The reaction is catalyzed by an inexpensive and bench-stable iron complex and generally occurs at ambient temperature. The transformation likely proceeds through hydromagnesiation of the vinyl group, and trapping of the in situ generated benzylic anion by an intramolecular electrophile to form the heterocycle. This iron-catalyzed strategy was shown to be broadly applicable and was utilized in the synthesis of substituted indoles, oxindoles and tetrahydrobenzoazepinoindolone derivatives. Mechanistic studies indicated that the reversibility of the hydride transfer step depends on the reactivity of the tethered electrophile. The synthetic utility of our approach was further demonstrated by the formal synthesis of a reported bioactive compound and a family of natural products.

PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR

The present disclosure provides pyrimidine compounds of Formula 1 and uses thereof, for example, for the potential treatment of diseases associated with P2X purinergic receptors. In certain aspects, the present disclosure provides P2X3 and/or P2X2/3 antagonists which are useful, for example, for the potential treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.

A Regiocontrolled Synthesis of Substituted Indoles by Palladium-Catalyzed Coupling of 2-Bromonitrobenzenes and 2-Bromoacetanilides

The palladium-catalyzed cross-coupling reaction of 2-bromonitrobenzenes or 2-bromoacetanilides with ethylene has been used to produce a variety of substituted indoles.The mild reaction conditions and selectivity inherent in the coupling reaction have been utilized to produce regiochemically pure 4-, 5-, 6-, and 7-substituted indoles.