127-58-2 Usage
Description
Sulfamerazine sodium is a sulfonamide antibiotic that exhibits bacteriostatic properties by inhibiting bacterial synthesis of dihydrofolic acid. It is effective in treating various infections and has been used in formulations for pneumonia and typhoid fever treatment.
Uses
Used in Pharmaceutical Industry:
Sulfamerazine sodium is used as an active pharmaceutical ingredient for the development of medications targeting bacterial infections. Its ability to inhibit bacterial carbonic anhydrase and prevent the synthesis of dihydrofolic acid makes it a potent agent against pneumonia and typhoid fever.
Used in Veterinary Medicine:
Sulfamerazine sodium is used as a veterinary drug to treat and prevent bacterial infections in animals. It helps reduce the severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice, thus contributing to improved animal health.
Used in Drug Delivery Systems:
Sulfamerazine sodium is involved in the characterization of chirosoan membranes for the transport of drugs. This application aids in the development of advanced drug delivery systems that can enhance the efficacy and targeted delivery of sulfamerazine sodium to treat various bacterial infections more effectively.
World Health Organization (WHO)
Sulfamerazine sodium, a sulfonamide anti-infective agent, was
introduced several decades ago for the treatment of bacterial infections. The
importance of sulfonamides has subsequently decreased as a result of increasing
resistance and their replacement by antibiotics which are generally more active
and less toxic. The sulfonamides are known to cause serious adverse effects such
as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma
and dangerous adverse reactions affecting blood formation such as
agranulocytosis and haemolytic or aplastic anaemia. Sulfamerazine is still used in
some countries usually in combination with other sulfonamides.
Safety Profile
Moderately toxic by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.
Check Digit Verification of cas no
The CAS Registry Mumber 127-58-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127-58:
(5*1)+(4*2)+(3*7)+(2*5)+(1*8)=52
52 % 10 = 2
So 127-58-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N4O2S.Na/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10;/h2-7H,12H2,1H3;/q-1;+1
