127095-97-0

Basic information

• Product Name: BOC-3,4-DIMETHOXY-L-PHENYLALANINE
• Synonyms: (S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,4-DIMETHOXY-PHENYLALANINE;(S)-BOC-3,4-DIMETHOXYPHENYLALANINE;(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPIONIC ACID;N-BOC-3,4-DIMETHOXY-L-PHENYLALANINE;N-BOC-(S)-3,4-DIMETHOXYPHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-L-(3-METHOXY,4-METHYL)TYROSINE;N-ALPHA-T-BUTOXYCARBONYL-L-(3,4-DIMETHOXY)PHENYLALANINE;L-TYROSINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-METHOXY-O-METHYL-
• CAS NO: 127095-97-0
• Molecular Formula: C₁₆H₂₃NO₆
• Molecular Weight: 325.36
• Mol File: 127095-97-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 482.706 °C at 760 mmHg
• Flash Point: 245.732 °C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Store at 0°C
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: BOC-3,4-DIMETHOXY-L-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-3,4-DIMETHOXY-L-PHENYLALANINE(127095-97-0)
• EPA Substance Registry System: BOC-3,4-DIMETHOXY-L-PHENYLALANINE(127095-97-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 127095-97-0(Hazardous Substances Data)

Usage

General Description

BOC-3,4-DIMETHOXY-L-PHENYLALANINE is a chemical compound with the molecular formula C17H23NO5. It is an amino acid derivative and a derivative of phenylalanine. BOC-3,4-DIMETHOXY-L-PHENYLALANINE is used in organic synthesis and pharmaceutical research as a building block for the preparation of various bioactive compounds and pharmaceutical drugs. It is commonly used as a precursor in the synthesis of peptides and peptidomimetics, as well as in the development of new drugs for the treatment of various diseases. Additionally, this compound has potential applications in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C16H23NO6/c1-16(2,3)23-15(20)17-11(14(18)19)8-10-6-7-12(21-4)13(9-10)22-5/h6-7,9,11H,8H2,1-5H3,(H,17,20)(H,18,19)/t11-/m0/s1

Upstream product

• 30033-24-0 (2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 59-92-7 levodopa 
• 138908-56-2 (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 

Downstream Products

• 538367-15-6 (S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester 
• 138908-56-2 (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 

Relevant articles and documents

Photocyclization of Tetra- and Pentapeptides Containing Adamantylphthalimide and Phenylalanines: Reaction Efficiency and Diastereoselectivity

A series of tetrapeptides and pentapeptides was synthesized bearing a phthalimide chromophore at the N-terminus. The C-terminus of the peptides was strategically substituted with an amino acid, Phe, Phe(OMe), or Phe(OMe)2 characterized by different oxidation potentials. The photochemical reactivity of the peptides was investigated by preparative irradiation and isolation of photoproducts, as well as with laser flash photolysis. Upon photoexcitation, the peptides undergo photoinduced electron transfer (PET) and decarboxylation, followed by diastereoselective cyclization with the retention of configuration for tetrapeptides or inversion of configuration for pentapeptides. Molecular dynamics (MD) simulations and NOE experiments enabled assignment of the stereochemistry of the cyclic peptides. MD simulations of the linear peptides disclosed conformational reasons for the observed diastereoselectivity, being due to the peptide backbone spatial orientation imposed by the Phe amino acids. The photochemical efficiency for the decarboxylation and cyclization is not dependent on the peptide length, but it depends on the oxidation potential of the amino acid at the C-terminus. The results described herein are particularly important for the rational design of efficient photochemical reactions for the preparation of cyclic peptides with the desired selectivity.

Synthesis of tetrahydroisoquinoline-based pseudopeptides and their characterization as suitable reverse turn mimetics

New peptidomimetics containing the Tic moiety were synthesized in enantiomerically pure form and their conformational features were studied by NMR, IR, and molecular modeling techniques. The presence of a reverse turn conformation was observed in all the

Enantioselective synthesis of pyrrolo[2,1-a]isoquinolones via stereocontrolled N-acyliminium ion cyclisations

Stereocontrolled N-acyliminium ion cyclisation of L-DOPA derived succinimide 5 has been investigated. Addition of organolithiums to chiral non-racemic 5 yields oxoamides, which are cyclised diastereoselectively upon treatment with BF3·OEt2, to afford 5,10b-trans pyrroloisoquinolones in moderate yields and high ee (99%).