127462-35-5

Basic information

• Product Name: Benzeneacetamide, -alpha-,4-dimethyl-
• Synonyms: Benzeneacetamide, -alpha-,4-dimethyl-;2-p-tolylpropanaMide
• CAS NO: 127462-35-5
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• Mol File: 127462-35-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetamide, -alpha-,4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, -alpha-,4-dimethyl-(127462-35-5)
• EPA Substance Registry System: Benzeneacetamide, -alpha-,4-dimethyl-(127462-35-5)

Safety Data

• Hazardous Substances Data: 127462-35-5(Hazardous Substances Data)

Upstream product

• 89-74-7 2,4-dimethylacetophenone. 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 201230-82-2 carbon monoxide 
• 69813-79-2 2-(4-tolyl)-2-(trimethylsiloxy)propanenitrile 
• 75920-45-5 (+/-)-2-(4'-methylphenyl)-propionitrile 

Relevant articles and documents

Cobalt-Catalyzed 1,4-Aryl Migration/Desulfonylation Cascade: Synthesis of α-Aryl Amides

A cobalt-catalyzed 1,4-aryl migration/disulfonylation cascade applied to α-bromo N-sulfonyl amides was developed. The reaction was highly chemoselective, allowing the preparation of α-aryl amides possessing a variety of functional groups. The method was used as the key step to synthesize an alkaloid, (±)-deoxyeseroline. Mechanistic investigations suggest a radical process.

Primary fatty acid amide preparation method

The present invention provides a primary fatty acid amide preparation method. According to the present invention, under the action of a single auxiliary agent phosphine-containing transition metal catalyst or a combined auxiliary agent comprising a phosphine-free transition metal catalyst and a phosphine-containing ligand, terminally substituted olefin or cyclo-olefin, carbon monoxide and an ammonium salt are subjected to a hydrogen carboamidation reaction so as to prepare the primary fatty acid amide compound in one step; the raw material and the catalyst of the reaction are inexpensive and easy to obtain, and the synthesis process is simple, such that the synthesis cost is substantially reduced; the preparation method has characteristics of mild reaction condition and high yield, and issuitable for industrial production; and the raw material and the catalyst of the reaction are clean, non-toxic and low environment pollution.

A convenient reductive removal of benzylic hydroxyl and trimethylsilyloxyl groups with Me3SiCl-NaI-MeCN reagent

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