127852-24-8

Basic information

• Product Name: (R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL
• Synonyms: R-MTF-PEL;(R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL;(1R)-1-[3-(Trifluoromethyl)phenyl]ethan-1-ol;(alphaR)-3-Trifluoromethyl-alpha-methylbenzenemethanol;(αR)-α-Methyl-3-(trifluoromethyl)-benzenemethanol;(αR)-α-Methyl-3-(trifluoromethyl)-benzenemethanol,99%e.e.;Benzenemethanol, a-methyl-3-(trifluoromethyl)-, (aR)-
• CAS NO: 127852-24-8
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.16
• Mol File: 127852-24-8.mol
• Article Data: 118

Chemical Properties

• Boiling Point: 206.9 °C at 760 mmHg
• Flash Point: 96.1 °C
• Appearance: /
• Density: 1.234 g/cm³
• Vapor Pressure: 0.14mmHg at 25°C
• Refractive Index: 1.461
• CAS DataBase Reference: (R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL(127852-24-8)
• EPA Substance Registry System: (R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL(127852-24-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 127852-24-8(Hazardous Substances Data)

Usage

General Description

"(R)-1-[3-(Trifluoromethyl)phenyl]ethanol, also known as (R)-α-(3-Trifluoromethylphenyl)ethanol, is an organic chemical compound. This chiral chemical is primarily used in research and industrial applications. Structurally, it features an ethanol group attached to a trifluoromethylated phenyl ring. The prefix "(R)" refers to the particular orientation of the compound's stereochemistry as per the Cahn–Ingold–Prelog priority rules. Its formula is C9H9F3O. As with many fluoroorganic compounds, it has properties influenced by the presence of the highly electronegative fluorine atoms, which can alter chemical reactivity and molecular properties.

InChI:InChI=1/C9H9F3O/c1-6(13)7-3-2-4-8(5-7)9(10,11)12/h2-6,13H,1H3/t6-/m1/s1

Upstream product

• 402-24-4 3-(trifluoromethyl)styrene 
• 108-05-4 vinyl acetate 
• 32313-84-1 (+/-)-1-(3-trifluoromethylphenyl)ethyl acetate 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 75-24-1 trimethylaluminum 
• 99705-50-7 1-[3-(trifluoromethyl)phenyl]ethanone oxime 
• 454-91-1 1-(3-trifluoromethylphenyl)ethanol 
• 67-63-0 isopropyl alcohol 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 170876-31-0 C₁₅H₂₃F₃O₃Si 
• 1620164-40-0 rac-1-(3-(trifluoromethyl)phenyl)ethyl sulfate 
• 181934-73-6 C₉H₈Cl₃F₃Si 
• 98-16-8 3-trifluoromethylaniline 
• 274-07-7 benzo[1,3,2]dioxaborole 

Downstream Products

• 208196-20-7 (R)-1-chloro-1-(3-trifluoromethylphenyl)ethane 
• 3803-25-6 (1R)-1-[3-(trifluoromethyl)phenyl]ethan-1-amine hydrochloride 
• 1396007-14-9 (R)-1-{4'-[1-methyl-5-((1-(3-(trifluoromethyl)-phenyl)ethoxy)-carbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1292296-28-6 thioacetic acid S-[(R)-1-(3-trifluoromethylphenyl)ethyl] ester 
• 1292296-62-8 C₁₇H₁₆F₃NOS 
• 1292296-73-1 methylthiocarbamic acid (S)-1-phenyl-1-(3-trifluoromethylphenyl)ethyl ester 
• 1227622-58-3 (R)-3-[5-chloro-2-[1-(3-trifluoromethyl-phenyl)-ethoxy]-phenoxy]-azetidine-1-carboxylic acid tert-butyl ester 
• 1100696-86-3 C₁₆H₁₂BrF₃O₂ 
• 1100696-89-6 C₁₆H₁₂BrF₃O₂ 

Relevant articles and documents

Synthesis and Applications of HexaPHEMP, a Novel Biaryl Diphosphine Ligand

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Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

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Arene-Immobilized Ru(II)/TsDPEN Complexes: Synthesis and Applications to the Asymmetric Transfer Hydrogenation of Ketones

The Noyori-Ikariya (arene)Ru(II)/TsDPEN precatalyst has been anchored to amorphous silica and DAVISIL through the η6-coordinated arene ligand via a straightforward synthesis and the derived systems, (arene)Ru(II)/TsDPEN@silica and (arene)Ru(II)/TsDPEN@DAVISIL, form highly efficient catalysts for the asymmetric transfer hydrogenation of a range of electron-rich and electron-poor aromatic ketones, giving good conversion and excellent ee's under mild reaction conditions. Moreover, catalyst generated in situ immediately prior to addition of substrate and hydrogen donor, by reaction of silica-supported [(arene)RuCl2]2 with (S,S)-TsDPEN, was as efficient as that generated from its preformed counterpart [(arene)Ru{(S,S)-TsDPEN}Cl]@silica. Gratifyingly, the initial TOFs (up to 1085 h?1) and ee's (96–97 %) obtained with these catalysts either rivalled or outperformed those previously reported for catalysts supported by either silica or polymer immobilized through one of the nitrogen atoms of TsDPEN. While the high ee's were also maintained during recycle studies, the conversion dropped steadily over the first three runs due to gradual leaching of the ruthenium.