1282-40-2Relevant articles and documents
Chandra, Kailash,Sharma, R. K.,Garg, B. S.,Singh, R. P.
, p. 125 - 128 (1979)
Water soluble, hydrolytically stable derivatives of the antitumor drug titanocene dichloride and binding studies with nucleotides
Mokdsi, George,Harding, Margaret M.
, p. 29 - 35 (1998)
The rate of hydrolysis of the aromatic rings of Cp2TiX2 and the dimethylsubstituted derivatives (MeCp)2TiX2 [X=Cl, O2CCH2NH3Cl], in aqueous solutions at pH 2-8 have been studied
Titanium(IV) carboxylate complexes: Synthesis, structural characterization and cytotoxic activity
Gómez-Ruiz, Santiago,Gallego, Beatriz,?i?ak, ?eljko,Hey-Hawkins, Evamarie,Jurani?, Zorica D.,Kaluderovi?, Goran N.
, p. 354 - 360 (2010/04/04)
Four titanium(IV) carboxylate complexes [Ti(η5-C5H5)2 (O2CCH2SMes)2] (1), [Ti(η5-C5H4Me)2 (O2CCH2SMes)2] (2), [Ti(η5-C5H5)(η5 -C5H4SiMe3)(O2CCH2SMes )2] (3) and [Ti(η5-C5Me5)(O2CCH 2SMes)3] (4; Mes = 2,4,6-Me3C6H2) have been synthesised by the reaction of the corresponding titanium derivatives [Ti(η5-C5H5)2Cl 2], [Ti(η5-C5H4Me) 2Cl2], [Ti(η5-C5H5)(η5 -C5H4SiMe3)Cl2] and [Ti(η5-C5Me5)Cl3] and two (for 1-3) or three (for 4) equivalents of mesitylthioacetic acid. Complexes 1-4 have been characterized by spectroscopic methods and the molecular structure of the complexes 1, 2 and 4 have been determined by X-ray diffraction studies. The cytotoxic activity of 1-4 was tested against tumor cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x, and normal immunocompetent cells, that is peripheral blood mononuclear cells PBMC and compared with those of the reference complexes [Ti(η5-C5H5)2Cl 2] (R1), [Ti(η5-C5H4Me)2Cl 2] (R2), [Ti(η5-C5H5)(η5 -C5H4SiMe3)Cl2] (R3) and cisplatin. In all cases, the cytotoxic activity of the carboxylate derivatives was higher than that of their corresponding dichloride analogues, indicating a positive effect of the carboxylato ligand on the final anticancer activity. Complexes 1-4 are more active against K562 (IC50 values from 72.2 to 87.9 μM) than against HeLa (IC50 values from 107.2 to 142.2 μM) and Fem-x cells (IC50 values from 90.2 to 191.4 μM).
Sulfur Compounds, 187. Synthesis of Bis(trichloromethyl)tetra- and -heptasulfane from Titanocene Polysulfide Complexes and Structure of (CCl3)2S7
Steudel, Ralf,Pridoehl, Markus,Buschmann, Juergen,Luger, Peter
, p. 725 - 728 (2007/10/03)
CCl3SCl reacts with (C5H5)2TiS5 to give the heptasulfane (CCl3)2S7 which forms colorless crystals of m.p. 38 deg C.An X-ray structural analysis revealed that the C-S7-C chain is helical but the CCl3 groups are slightly tilted.In the triclinic crystals the molecules are arranged parallel to each other.Decomposition of (CCl3)2S7 provides other members of the homologous series with 4-12 sulfur atoms as shown by HPLC analysis.The reaction of CCl3SCl with (C5H4CH3)4Ti2S4 yields colorless crystals of (CCl3)2S4, demonstrating the usefulness also of dinuclear titanocene polysulfide complexes for the synthesis of organic polysulfanes.Infrared, Raman, and 13C-NMR spectra of (CCl3)2S4 and (CCl3)2S7 are reported. - Keywords: Organic polysulfanes; Titanocene compounds; Sulfur ligand transfer; Chain length equilibration; Sulfur helix