1286737-11-8

Basic information

• Product Name: C₂₇H₃₆N₁₂O₄
• Synonyms: C₂₇H₃₆N₁₂O₄
• CAS NO: 1286737-11-8
• Molecular Weight: 592.661
• Mol File: 1286737-11-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₆N₁₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₆N₁₂O₄(1286737-11-8)
• EPA Substance Registry System: C₂₇H₃₆N₁₂O₄(1286737-11-8)

Safety Data

• Hazardous Substances Data: 1286737-11-8(Hazardous Substances Data)

Upstream product

• 88192-19-2 3-azidopropylamine 
• 79640-70-3 (S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 

Downstream Products

• 1286737-12-9 γ-azido-MTX 

Relevant articles and documents

Copper-free click conjugation of methotrexate to a PAMAM dendrimer platform

The synthesis of a generation 5 (G5) poly(amidoamine) (PAMAM) dendrimer platform having cyclooctyne ligands that were subsequently be used for a copper-free Huisgen 1,3-dipolar cycloaddition (click reaction) with azido modified methotrexate is described.

Multifunctional small molecules

The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of us

The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry

The facile conjugation of three azido modified functionalities, namely a therapeutic drug (methotrexate), a targeting moiety (folic acid), and an imaging agent (fluorescein) with a G5 PAMAM dendrimer scaffold with cyclooctyne molecules at the surface thro