128833-03-4 Usage
Description
DIETHYL 3-BROMOBENZYLPHOSPHONATE is an organic compound that serves as a reagent in chemical reactions, particularly in the conversion of benzylic and allylic alcohols to phosphonates. It is characterized by its bromo-benzyl group attached to a phosphonate moiety, which plays a crucial role in its reactivity and applications.
Uses
Used in Pharmaceutical Industry:
DIETHYL 3-BROMOBENZYLPHOSPHONATE is used as a reagent for the synthesis of various pharmaceutical compounds. Its ability to convert benzylic and allylic alcohols to phosphonates makes it a valuable tool in the development of new drugs and medicinal agents.
Used in Chemical Research:
In the field of chemical research, DIETHYL 3-BROMOBENZYLPHOSPHONATE is employed as a reagent to study the reactivity and properties of benzylic and allylic alcohols. This helps researchers to understand the underlying mechanisms of various chemical reactions and develop new synthetic routes for the production of complex organic molecules.
Used in Organic Synthesis:
DIETHYL 3-BROMOBENZYLPHOSPHONATE is used as a reagent in organic synthesis for the preparation of phosphonate derivatives. These derivatives are important intermediates in the synthesis of various organic compounds, including agrochemicals, dyes, and specialty chemicals.
Used in Material Science:
In material science, DIETHYL 3-BROMOBENZYLPHOSPHONATE can be used as a reagent to modify the properties of certain materials. The introduction of phosphonate groups can enhance the stability, solubility, or reactivity of these materials, making them suitable for various applications, such as catalysts, sensors, or coatings.
Overall, DIETHYL 3-BROMOBENZYLPHOSPHONATE is a versatile reagent with applications in various industries, including pharmaceuticals, chemical research, organic synthesis, and material science. Its ability to convert benzylic and allylic alcohols to phosphonates makes it a valuable tool for the development of new compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 128833-03-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,8,3 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 128833-03:
(8*1)+(7*2)+(6*8)+(5*8)+(4*3)+(3*3)+(2*0)+(1*3)=134
134 % 10 = 4
So 128833-03-4 is a valid CAS Registry Number.
128833-03-4Relevant articles and documents
The preparation of heterobiaryl phosphonates via the Stille coupling reaction
Kennedy, Gordon,Perboni, Alcide D.
, p. 7611 - 7614 (1996)
The Stille cross-coupling reaction between various heteroarylstannanes and substituted bromo-benzylphosphonates was used to prepared heterobiaryl phosphonates in moderate to good yields.
Selective esterification of phosphonic acids
Brodzka, Anna,Koszelewski, Dominik,Ostaszewski, Ryszard,Trzepizur, Damian
, (2021/09/27)
Here, we report straightforward and selective synthetic procedures for mono-and diesteri-fication of phosphonic acids. A series of alkoxy group donors were studied and triethyl orthoacetate was found to be the best reagent as well as a solvent for the performed transformations. An important temperature effect on the reaction course was discovered. Depending on the reaction temperature, mono-or diethyl esters of phosphonic acid were obtained exclusively with decent yields. The sub-strate scope of the proposed methodology was verified on aromatic as well as aliphatic phosphonic acids. The designed method can be successfully applied for small-and large-scale experiments without significant loss of selectivity or reaction yield. Several devoted experiments were performed to give insight into the reaction mechanism. At 30?C, monoesters are formed via an intermediate (1,1-diethoxyethyl ester of phosphonic acid). At higher temperatures, similar intermediate forms give diesters or stable and detectable pyrophosphonates which were also consumed to give diesters.31P NMR spectroscopy was used to assign the structure of pyrophosphonate as well as to monitor the reaction course. No need for additional reagents and good accessibility and straightforward purification are the important aspects of the developed protocols.
Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes
Huang, Tianzeng,Chen, Tieqiao,Han, Li-Biao
, p. 2959 - 2965 (2018/03/09)
Under a dioxygen atmosphere, benzylphosphonates and related phosphoryl compounds can readily produce the corresponding trans-stilbenes in high yields with high selectivity upon treatment with bases. Various functional groups were tolerable under the reaction conditions.
