128914-46-5 Usage
Description
(±)16-HETE, also known as hydroxyeicosatetraenoic acid, is a racemic mixture of the minor CYP450 metabolite of arachidonic acid, which plays a crucial role in regulating electrolyte and fluid transport in the kidney. It is released by the kidney upon angiotensin II stimulation and exhibits stereospecific biological activity, with distinct effects of its (R) and (S) enantiomers on vasodilation and ATPase activity.
Used in Pharmaceutical Industry:
(±)16-HETE is used as a research compound for studying the role of arachidonic acid metabolites in kidney function and their potential therapeutic applications in treating kidney-related disorders. The distinct effects of its enantiomers on vasodilation and ATPase activity make it a valuable tool for understanding the underlying mechanisms of kidney function and developing targeted therapies.
Used in Biomedical Research:
(±)16-HETE is used as a bioactive molecule in biomedical research to investigate the stereospecific effects of arachidonic acid metabolites on various physiological processes, such as vasodilation and ATPase activity inhibition. This knowledge can contribute to the development of novel therapeutic strategies for managing kidney diseases and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 128914-46-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,9,1 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 128914-46:
(8*1)+(7*2)+(6*8)+(5*9)+(4*1)+(3*4)+(2*4)+(1*6)=145
145 % 10 = 5
So 128914-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O3/c1-2-3-16-19(21)17-14-12-10-8-6-4-5-7-9-11-13-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14-
128914-46-5Relevant articles and documents
Repurposing Resveratrol and Fluconazole to Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism
El-Sherbeni, Ahmed A.,El-Kadi, Ayman O. S.
, p. 1278 - 1288 (2016/04/26)
Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Repurposing clinically-approved drugs could provide safe and readily available means
Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity
Reddy, Y. Krishna,Reddy, L. Manmohan,Capdevila, Jorge H.,Falck
, p. 3719 - 3720 (2007/10/03)
An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.
