129245-22-3

Basic information

• Product Name: N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid
• Synonyms: N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid
• CAS NO: 129245-22-3
• Molecular Weight: 594.751
• Mol File: 129245-22-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid(129245-22-3)
• EPA Substance Registry System: N-(4-cyanobutyl)-3-<<5-<(benzyloxy)-tert-butoxy-carbonylamino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid(129245-22-3)

Safety Data

• Hazardous Substances Data: 129245-22-3(Hazardous Substances Data)

Upstream product

• 128173-50-2 O-Benzyl-N-(tert-butoxycarbonyl)-N-(4-cyanobutyl)-hydroxylamine 
• 112139-59-0 O-benzyl-N-(4-cyanobutyl)-hydroxylamine 
• 79722-21-7 tert-butyl N-(benzyloxy)carbamate 
• 6280-87-1 δ-chlorovaleronitrile 
• 129245-21-2 O-benzyl-N-(5-aminopentyl)-N-(tert-butoxycarbonyl)hydroxylamine 
• 112139-60-3 N-(4-Cyanobutyl)-N-(benzyloxy)succinamic Acid 

Downstream Products

• 129245-23-4 N-(4-cyanobutyl)-3-<<5-<(benzyloxy)amino>pentyl>carbamoyl>-O-benzylpropionohydroxamic acid 
• 135638-85-6 22-(tert-butoxycarbonyl)-11,22-bis(benzyloxy)-12,15-dioxo-11,16,22-triaza-2,5,8-trioxadocosane 
• 112139-65-8 N'-<5-<<4-<<5-pentyl>amino>-1,4-dioxobutyl>(phenylmethoxy)amino>pentyl>-N-(4-cyanobutyl)-N-(phenylmethoxy)butanediamide 
• 130946-40-6 27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile 
• 130946-41-7 27--6,17-bis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22-tetraazaheptacosanenitrile 
• 70-51-9 deferoxamine 
• 112972-60-8 bisucaberin 
• 129245-26-7 6,17-bis(benzyloxy)-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetrone 
• 129245-25-6 21-amino-5,16-bis(benzyloxy)-4,12,15-trioxo-5,11,16-triazaheneicosanoic acid 
• 129245-24-5 5,16-bis(benzyloxy)-20-cyano-4,12,15-trioxo-5,11,16-triazaeicosanoic acid 

Relevant articles and documents

THE TOTAL SYNTHESIS OF BISUCABERIN

The first total synthesis of 6,17-dihydroxy-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetrone (bisucaberin) is presented.The synthetic scheme employed in this study illustrates the utility of O-benzyl-N-(tert-butoxycarbonyl)-N-(4-cyanobutyl)hydroxylamine

Synthesis and biological evaluation of hydroxamate-based iron chelators

A new and versatile route to desferrioxamine B (DFO, 1) is described. Hydroxamate reagent 4 was elaborated in a series of high yield steps to the tert-butoxycarbonyl nitrile 11, which provided DFO in three transformations. The intermediate 11 could also be utilized in the preparation of DFO analogues which contain terminal N-acyl groups other than acetyl. The methodology was further employed in the syntheses of the DFO polyether analogues 2 and 3, beginning with the 3,6,9-trioxadecylation of N-(tert- butoxycarbonyl)-O-benzylhydroxylamine. Polyethers 2 and 3 are neutral molecules, which are somewhat more lipophilic than the parent DFO. Polyether hydroxamate 2 was shown to be nearly 3 times as effective as desferrioxamine at clearing iron in rats.