1292802-63-1

Basic information

• Product Name: C₁₃H₉ClFN₃O
• Synonyms: C₁₃H₉ClFN₃O
• CAS NO: 1292802-63-1
• Molecular Weight: 277.685
• Mol File: 1292802-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₉ClFN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₉ClFN₃O(1292802-63-1)
• EPA Substance Registry System: C₁₃H₉ClFN₃O(1292802-63-1)

Safety Data

• Hazardous Substances Data: 1292802-63-1(Hazardous Substances Data)

Upstream product

• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 

Downstream Products

• 1292802-52-8 C₂₉H₃₅FN₆O 
• 1292802-54-0 C₂₇H₂₉Cl₂FN₆O 
• 1292802-51-7 C₂₀H₁₇FN₄O₂ 
• 1292802-53-9 C₂₈H₃₃FN₆O 

Relevant articles and documents

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.