1293293-73-8

Basic information

• Product Name: (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid
• Synonyms: (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid
• CAS NO: 1293293-73-8
• Molecular Weight: 259.188
• Mol File: 1293293-73-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid(1293293-73-8)
• EPA Substance Registry System: (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid(1293293-73-8)

Safety Data

• Hazardous Substances Data: 1293293-73-8(Hazardous Substances Data)

Usage

Description

(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid, also known as trifluoromethyl phenyl butyric acid azide, is a chiral chemical compound that features a butyric acid backbone with an azido group and a trifluorophenyl group attached. The (3R) stereochemistry signifies the specific spatial arrangement of atoms in the molecule, which is crucial for its reactivity and potential applications.

Uses

Used in Organic Synthesis:
(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid is utilized as a key intermediate in organic synthesis for the creation of complex organic molecules. Its unique structure allows for versatile reactions and the formation of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid serves as a starting material for the preparation of pharmaceutical compounds. Its reactivity and the ability to modify the azido group make it an ideal candidate for the development of new drugs with potential therapeutic applications.
Used in Drug Discovery:
(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid is also employed in drug discovery processes, where its trifluorophenyl group contributes to high reactivity, and the azido group provides opportunities for further functionalization. This makes (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid a valuable tool for creating novel drug candidates with improved pharmacological properties.
Used in Pharmaceutical Industry:
(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid is used as a building block in the pharmaceutical industry for the development of new drugs. Its unique structural features and the potential for chemical modifications make it a promising component in the design and synthesis of innovative therapeutic agents.

Upstream product

• 1253055-97-8 (R)-methyl 3-azido-4-(2,4,5-trifluorophenyl)butanoate 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 1246960-15-5 (S)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-ol 
• 1283096-72-9 (2S)-2-(2,4,5-trifluorobenzyl)-oxirane 
• 1293293-72-7 (2S)-1-(2-azido-4-pentenyl)-2,4,5-trifluorobenzene 
• 1293293-71-6 (2R)-1-(2,4,5-trifluorophenyl)-4-pentene-2-ol 
• 1329036-41-0 C₁₂H₁₃F₃O₃S 

Downstream Products

• 1253055-98-9 (R)-3-azido-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one 
• 1329036-50-1 (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid dibenzylamine salt 
• 1329036-44-3 (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt 
• 1329036-47-6 (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid 2,2-diphenylethylamine salt 
• 486460-32-6 sitagliptin 
• 654671-78-0 sitagliptin phosphate 
• 1329036-54-5 C₁₀H₇ClF₃N₃O 

Relevant articles and documents

METHOD FOR PREPARING SITAGLIPTIN AND AMINE SALT INTERMEDIATES USED THEREIN

The present invention relates to a method for preparing sitagliptin by using an amine salt of (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid (formula (V)) in a high yield and purity, and amine salt intermediates used therein.

PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES

The present invention relates to novel and improved processes for the preparation of Sitagliptin compound of formula (1) and its intermediates.