1296832-76-2

Basic information

• Product Name: Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide
• Synonyms: Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide;1-[[[[1-Carboxy-2-[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]ethyl]thio]carbonyl]aMino]-1-deoxy-β-D-glucopyranuronic Acid
• CAS NO: 1296832-76-2
• Molecular Formula: C₂₅H₃₀N₂O₁₀S
• Molecular Weight: 550.5781
• Product Categories: Aromatics;Glucuronides;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 1296832-76-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.50±0.1 g/cm3(Predicted)
• PKA: 2.81±0.70(Predicted)
• CAS DataBase Reference: Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide(1296832-76-2)
• EPA Substance Registry System: Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide(1296832-76-2)

Safety Data

• Hazardous Substances Data: 1296832-76-2(Hazardous Substances Data)

Usage

Description

Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide is a ring-opened metabolite of Pioglitazone, which is formed through the N-glucuronidation of the thiazolidinedione ring. This metabolite is derived from Pioglitazone, a medication used to treat type 2 diabetes.

Uses

Used in Pharmaceutical Industry:
Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide is used as an active metabolite for the treatment of type 2 diabetes. It is formed in the body after the administration of Pioglitazone and contributes to the drug's therapeutic effects by improving insulin sensitivity and glucose control.
Used in Research and Development:
This metabolite is also used in research and development for understanding the metabolic pathways of Pioglitazone and its potential effects on glucose metabolism and insulin sensitivity. It can be utilized in the development of new drugs or therapies for type 2 diabetes and related metabolic disorders.
Used in Quality Control and Drug Analysis:
Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide is used as a reference compound in the quality control and analysis of Pioglitazone-containing pharmaceutical products. It helps ensure the efficacy, safety, and consistency of these medications by providing a standard for comparison and measurement.

Upstream product

• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 
• 112529-15-4 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione hydrochloride 
• 1296832-72-8 3-((2R,3R,4S,5S,6S)-6-allyloxycarbonyl-3,4,5-trihydroxy-tetrahydropyran-2-yl)-5-{4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzyl}-thiazolidine-2,4-dione 
• 1296832-69-3 3-((2R,3R,4S,5S,6S)-3,4,5-triacetoxy-6-methoxycarbonyl-tetrahydropyran-2-yl)-5-{4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzyl}-thiazolidine-2,4-dione 
• 1296832-75-1 3-((2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydropyran-2-yl)-5-{4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzyl}-thiazolidine-2,4-dione 

Relevant articles and documents

Identification of novel metabolic pathways of pioglitazone in hepatocytes: N-glucuronidation of thiazolidinedione ring and sequential ring-opening pathway

The metabolism of [14C]pioglitazone was studied in vitro in incubations with freshly isolated human, rat, and monkey hepatocytes. Radioactivity detection high-performance liquid chromatography analysis of incubation extracts showed the detectio