1301133-25-4Relevant articles and documents
A silver-promoted solid-phase guanidylation process enables the first total synthesis of stictamide A
Li, Xiang,Li, Yu-Lei,Chen, Yan,Zou, Yan,Zhuo, Xiao-Bin,Wu, Qiu-Ye,Zhao, Qing-Jie,Hu, Hong-Gang
, p. 94654 - 94657 (2015/11/24)
The first total synthesis of stictamide A, a structurally unique peptide with a statine motif and a N-prenyl modified arginine in the side chain, is disclosed. The requisite statine was achieved via stereoselective hydrogenation of a functionalized ketone. The N-prenyl modified arginine was constructed by a novel silver-promoted solid-phase strategy for the first time. This synthetic method can be generally applied to the efficient synthesis of peptides containing statine and/or arginine N-alkylation groups.