1304385-08-7

Basic information

• Product Name: 4-iodophenyl isobutyl ether
• Synonyms: 4-iodophenyl isobutyl ether
• CAS NO: 1304385-08-7
• Molecular Weight: 276.117
• Mol File: 1304385-08-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-iodophenyl isobutyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodophenyl isobutyl ether(1304385-08-7)
• EPA Substance Registry System: 4-iodophenyl isobutyl ether(1304385-08-7)

Safety Data

• Hazardous Substances Data: 1304385-08-7(Hazardous Substances Data)

Upstream product

• 78-77-3 Isobutyl bromide 
• 540-38-5 p-Iodophenol 
• 513-38-2 Isobutyl iodide 

Downstream Products

• 1139901-88-4 tert-butyl 2-(3’-cyano-4’-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 
• 144060-53-7 febuxostat 
• 1139901-87-3 5-iodo-2-isobutoxy-benzonitrile 

Relevant articles and documents

Facile one-pot transformation of arenes into aromatic nitriles under metal-cyanide-free conditions

Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were treated with dichloromethyl methyl ether and ZnBr2, and then with molecular iodine and aq. ammonia to give the corresponding aromatic nitriles in good yields. Using this method, febuxostat was efficiently prepared from 4-bromophenol in four steps. The method can be used for the preparation of aromatic nitriles from arenes in one pot under metal-cyanide-free conditions. Various electron-rich arenes could be effectively converted into the corresponding aromatic nitriles in good yields, by treatment with ZnBr2 and dichloromethyl methyl ether, followed by reaction with molecular iodine and aq. ammonia.

New compounds, pharmaceutical compositions and uses thereof

The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.