131540-87-9 Usage
Description
6-Chloro-3-(piperazin-1-yl)benzol[d]isothiazole is an organic compound characterized by its chemical structure that features a benzol[d]isothiazole core with a chloro group at the 6th position and a piperazin-1-yl group attached at the 3rd position. 6-Chloro-3-(piperazin-1-yl)benzol[d]isothiazole is known for its potential applications in the pharmaceutical industry due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
6-Chloro-3-(piperazin-1-yl)benzol[d]isothiazole is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential therapeutic applications.
Used in the Preparation of [(piperazinyl)butyl]thiazolidinones:
6-Chloro-3-(piperazin-1-yl)benzol[d]isothiazole is used as a starting material for the preparation of [(piperazinyl)butyl]thiazolidinones derivatives, which exhibit a range of pharmacological activities.
Used in the Development of Anticonvulsant Agents:
6-Chloro-3-(piperazin-1-yl)benzol[d]isothiazole contributes to the development of anticonvulsant agents, as the [(piperazinyl)butyl]thiazolidinones derivatives synthesized from it have demonstrated anticonvulsant properties.
Used in the Development of Anxiolytic Agents:
The compound is also used in the development of anxiolytic agents, as the [(piperazinyl)butyl]thiazolidinones derivatives have shown anxiolytic activity, potentially benefiting patients suffering from anxiety disorders.
Used in the Development of Analgesic Agents:
6-Chloro-3-(piperazin-1-yl)benzol[d]isothiazole is utilized in the development of analgesic agents, as the synthesized [(piperazinyl)butyl]thiazolidinones derivatives possess analgesic properties, providing pain relief to patients in need.
Used in the Development of Antipsychotic Agents:
The compound plays a role in the development of antipsychotic agents, as the [(piperazinyl)butyl]thiazolidinones derivatives have exhibited antipsychotic activity, offering potential therapeutic benefits for individuals with psychotic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 131540-87-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,5,4 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 131540-87:
(8*1)+(7*3)+(6*1)+(5*5)+(4*4)+(3*0)+(2*8)+(1*7)=99
99 % 10 = 9
So 131540-87-9 is a valid CAS Registry Number.
131540-87-9Relevant articles and documents
Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics
Chen, Xiao-Wen,Sun, Yuan-Yuan,Fu, Lei,Li, Jian-Qi
, p. 332 - 353 (2016/08/04)
A series of novel benzisothiazolylpiperazine derivatives combining potent dopamine D2and D3, and serotonin 5-HT1Aand 5-HT2Areceptor properties were synthesized and evaluated for their potential antipsychotic properties. The most-promising derivative was 9j. The unique pharmacological features of 9j were a high affinity for D2, D3, 5-HT1A, and 5-HT2Areceptors, together with a 20-fold selectivity for the D3versus D2subtype, and a low affinity for muscarinic M1(reducing the risk of anticholinergic side effects), and for hERG channels (reducing incidence of QT interval prolongation). In animal behavioral models, 9j inhibited the locomotor-stimulating effects of phencyclidine, blocked conditioned avoidance response, and improved the cognitive deficit in the novel object recognition tests in rats. 9j exhibited a low potential for catalepsy, consistent with results with risperidone. In addition, favorable brain penetration of 9j in rats was detected. These studies have demonstrated that 9j is a potential atypical antipsychotic candidate.
