13214-66-9

Basic information

• Product Name: 4-PHENYLBUTYLAMINE
• Synonyms: 1-AMINO-4-PHENYLBUTANE 97+%;4-Phenyl-1-butylamine, 98+%;4-Phenylbutylamine,98%;Einecs 236-186-7;Benzenebutanamine;(4-AMINOBUTYL)-BENZENE;4-PHENYL-1-BUTYLAMINE;4-PHENYLBUTYLAMINE
• CAS NO: 13214-66-9
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.23
• EINECS: 236-186-7
• Product Categories: Amines;C9 to C10;Nitrogen Compounds
• Mol File: 13214-66-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 143°C (estimate)
• Boiling Point: 123-124 °C17 mm Hg(lit.)
• Flash Point: 215 °F
• Appearance: /
• Density: 0.944 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0373mmHg at 25°C
• Refractive Index: n20/D 1.519(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform, Methanol (Slightly)
• PKA: 10.66±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 2080045
• CAS DataBase Reference: 4-PHENYLBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLBUTYLAMINE(13214-66-9)
• EPA Substance Registry System: 4-PHENYLBUTYLAMINE(13214-66-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2735
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 13214-66-9(Hazardous Substances Data)

Usage

Description

4-Phenylbutylamine is an organic compound with the molecular formula C10H15N. It is a derivative of butylamine, featuring a phenyl group attached to the fourth carbon atom. 4-PHENYLBUTYLAMINE is known for its unique chemical properties and potential applications in various fields.

Uses

Used in Chemical Synthesis:
4-Phenylbutylamine is used as a chemical intermediate for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows it to be a versatile building block in the development of new compounds with specific properties and applications.
Used in Carbon Nanotube Modification:
4-Phenylbutylamine is used in the direct solvent-free amination of multi-walled carbon nanotubes. This process enhances the properties of carbon nanotubes, making them more suitable for applications in electronics, materials science, and other advanced technologies.
Used in Analytical Chemistry:
4-Phenylbutylamine is employed as an internal standard during solid-phase micro-extraction by gas chromatography (GC) technique for the detection of amphetamines in urine. Its consistent behavior under the same conditions as the target analytes allows for accurate quantification and improved reliability in the analysis of samples.

Biochem/physiol Actions

4-Phenylbutylamine is a competitive inhibitor of recombinant human liver monoamine oxidase A.

InChI:InChI=1/C10H15N/c11-9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9,11H2

Upstream product

• 1199-98-0 4-phenylbutyramide 
• 36603-28-8 5-phenylpentanitrile 
• 2046-18-6 4-phenylbutyronitrile 
• 768-56-9 4-Phenylbut-1-ene 
• 13633-25-5 1-Bromo-4-phenylbutane 
• 7664-41-7 ammonia 
• 7446-70-0 aluminium trichloride 
• 10026-13-8 phosphorus pentachloride 
• 859187-75-0 N-benzenesulfonyl-N-(4-phenyl-butyl)-glycine 
• 98-95-3 nitrobenzene 
• 71-43-2 benzene 
• 3360-41-6 4-phenyl-butan-1-ol 
• 64-17-5 ethanol 
• 54981-87-2 2-(4-phenylbutyl)-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 61499-10-3 Phenylbutyl isothiocyanate 
• 18983-94-3 (4-phenyl-butyl)-guanidine; sulfate 
• 100618-31-3 ethyl N-(4-phenylbutyl)carbamate 
• 136534-64-0 N-phenethyl-4-phenylbutan-1-amine 
• 129951-06-0 N-benzyl-4-phenylbutan-1-amine 
• 93406-12-3 N-benzoyl-4-phenylbutylamine 
• 100706-72-7 N²-(4-phenyl-butyl)-[1,3,5]triazine-2,4-diyldiamine 
• 101450-25-3 DL-N-Pantoyl-4-phenyl-butylamin 
• 109731-76-2 1-(4-phenyl-butyl)-biguanide 
• 20640-18-0 2-(4-Phenylbutylamino)-ethanthiol 
• 7576-39-8 N-(4-Phenyl-butyl)-exo-cis-7-oxa-bicyclo<2.2.1>-heptan-2,3-dicarbonimid 
• 1202-55-7 4-phenyl-1-(N,N-dimethylamino)butane 

Relevant articles and documents

Dehydrogenation of 2-Phenyl-1-pyrroline with Palladium-Supported Catalysts: An Effective Route to the Synthesis of 2-Phenylpyrrole

The catalytic dehydrogenation of 5-phenyl-3,4-dihydro-2H-pyrrole (2-phenyl-1-pyrroline) to 2-phenyl-1H-pyrrole in the presence of palladium-supported on activated carbon (Pd/C) or on alumina (Pd/Al2O3) is reported. Highly pure 2-phenylpyrrole is obtained in good yields and selectivities, in a ca. 20 gram-scale, after a simple work-up. The Pd/Al2O3 catalyst exhibited substantially higher activities than the Pd/C ones. (Figure Presented).

Enantioselective Copper(I)/Chiral Phosphoric Acid Catalyzed Intramolecular Amination of Allylic and Benzylic C?H Bonds

Radical-involved enantioselective oxidative C?H bond functionalization by a hydrogen-atom transfer (HAT) process has emerged as a promising method for accessing functionally diverse enantioenriched products, while asymmetric C(sp3)?H bond amination remains a formidable challenge. To address this problem, described herein is a dual CuI/chiral phosphoric acid (CPA) catalytic system for radical-involved enantioselective intramolecular C(sp3)?H amination of not only allylic positions but also benzylic positions with broad substrate scope. The use of 4-methoxy-NHPI (NHPI=N-hydroxyphthalimide) as a stable and chemoselective HAT mediator precursor is crucial for the fulfillment of this transformation. Preliminary mechanistic studies indicate that a crucial allylic or benzylic radical intermediate resulting from a HAT process is involved.

Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on "build-and-Scrap" Strategy

Utilizing radical chemistry, a new general C-C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthesis of furoxans but also short-step transformations of carboxylic acids to a broad range of functional groups.

Anodic benzylic C(sp3)-H amination: Unified access to pyrrolidines and piperidines

An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves anodic C-H activation to generate a benzylic cation, which is efficiently trapped by a nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6-membered ring formations.