132414-04-1

Basic information

• Product Name: 3,5-dimethyl-4-[(nitromethyl)sulfonyl]aniline
• Synonyms: 3,5-Dimethyl-4-((nitromethyl)sulfonyl)benzenamine; 4-Amino-2,6-dimethylphenylsulfonyl nitromethane
• CAS NO: 132414-04-1
• Molecular Formula: C₉H₁₂N₂O₄S
• Molecular Weight: 244.2676
• Mol File: 132414-04-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 484.5°C at 760 mmHg
• Flash Point: 246.8°C
• Density: 1.366g/cm³
• Vapor Pressure: 1.52E-09mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 3,5-dimethyl-4-[(nitromethyl)sulfonyl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethyl-4-[(nitromethyl)sulfonyl]aniline(132414-04-1)
• EPA Substance Registry System: 3,5-dimethyl-4-[(nitromethyl)sulfonyl]aniline(132414-04-1)

Safety Data

• Hazardous Substances Data: 132414-04-1(Hazardous Substances Data)

Upstream product

• 132414-07-4 (4-acetamido-2,6-dimethylphenyl)sulfinic acid 
• 2050-45-5 N-acetyl-3,5-dimethylaniline 
• 132414-03-0 (4-acetamido-2,6-dimethylphenylsulphonyl)nitromethane 

Downstream Products

• 210532-08-4 N-[3,5-Dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-2-thiophenesulphonamide 
• 210532-15-3 N-[3,5-Dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-4-biphenylsulphonamide 
• 210532-12-0 N-[3,5-Dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-4-(trifluoromethoxy)benzenesulphonamide 
• 210531-99-0 N-[3,5-Dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-2,2,2-trifluoroethanesulphonamide 
• 210531-90-1 N-[3,5-dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-2-(trifluoromethyl)benzenesulphonamide 
• 210532-01-7 N-[3,5-dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-3-fluorobenzenesulphonamide 
• 210531-98-9 N-[4-[3,5-dimethyl-4-[(nitromethyl)sulphonyl]phenylsulphamoyl]phenyl]acetamide 
• 141109-30-0 N,N-diethyl-N'-(3,5-dimethyl-4-[nitromethylsulfonyl]phenyl)oxamide 
• 141109-27-5 N-(3,5-dimethyl-4-[nitromethylsulfonyl]phenyl)-2-(2,6-dimethyl-1-piperidinyl)glyoxylamide 
• 140478-31-5 (2,6-dimethyl-4-[2-phenoxyacetamido]phenylsulfonyl)nitromethane 
• 210531-88-7 4-bromo-N-[3,5-dimethyl-4-[(nitromethyl)sulphonyl]phenyl]benzenesulphonamide 
• 210531-96-7 1-[3,5-dimethyl-4-[(nitromethyl)sulphonyl]phenyl]-3-[(2-methylphenyl)sulphonyl]urea 

Relevant articles and documents

Phenylsulfonylnitromethanes as potent irreversible inhibitors of aldose reductase

Aldose reductase (AR) inhibition provides a viable pharmacologically direct mode for the treatment of diabetic complications. We have synthesized a series of N-4 substituted analogues (15-21) of the known aldose reductase inhibitor phenyl-sulfonylnitromethane. The compounds are potent inhibitors of AR with IC50s between 0.01 and 0.19 μM. Some of the compounds are also potent affinity labels for AR. Compound 19 exhibits the highest and almost complete irreversible inhibition of AR known to date.

AMIDOBENZENE DERIVATIVES, COMPOSITIONS AND USE

The invention concerns novel phenoxy- and phenylthio-acetyl derivatives of (4-amino-2,6-dimethyl-phenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example,