13244-81-0

Basic information

• Product Name: (S)-2-Amino-4-[(R)-2-(2-amino-ethyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid
• Synonyms: (S)-2-Amino-4-[(R)-2-(2-amino-ethyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid
• CAS NO: 13244-81-0
• Molecular Weight: 382.462
• Mol File: 13244-81-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-Amino-4-[(R)-2-(2-amino-ethyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-4-[(R)-2-(2-amino-ethyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid(13244-81-0)
• EPA Substance Registry System: (S)-2-Amino-4-[(R)-2-(2-amino-ethyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid(13244-81-0)

Safety Data

• Hazardous Substances Data: 13244-81-0(Hazardous Substances Data)

Upstream product

• 27025-41-8 Oxidized glutathione 
• 60-23-1 Cysteamine 
• 70-18-8 GLUTATHIONE 
• 71899-86-0 S-<(3-carboxy-4-nitrophenyl)thio>-2-aminoethanethiol 
• 51-85-4 2,2'-dithio-bis[ethylamine] 

Downstream Products

• 27025-41-8 Oxidized glutathione 
• 60-23-1 Cysteamine 
• 70-18-8 GLUTATHIONE 
• 51-85-4 2,2'-dithio-bis[ethylamine] 

Relevant articles and documents

A kinetic approach to characterize the electrostatic environments of thiol groups in proteins

In this study, we synthesized a zwitterionic DTNB derivative, 5-(2- aminoethyl)-dithio-2-nitrobenzoate (ADNB), and characterized its reactions with several cationic, anionic, and neutral thiols. Reactions with ADNB, unlike those with DTNB, are relatively insensitive to electrostatic environments and ionic strengths. At relatively low ionic strength, rate ratios, k(ADNB)/k(DTNB), varied from 0.22 for reactions with low-molecular- weight cationic thiols to 3.0 for those with low-molecular-weight anionic thiols. A k(ADNB)/k(DTNB) ratio of ~200 for Cys-34 of BSA appears to reflect a very anionic environment. k(ADNB)/k(DTNB) ratios of ~6 and ~1, respectively, for canine and equine serum albumins, which have Glu-82 → Asp and Glu-82 → Ala substitutions suggest Glu-82 is the most important anionic residues affecting the reactivity of Cys-34 in BSA. k(ADNB)/k(DTNB) ratios appear to be useful for characterizing electrostatic environments of thiol groups in proteins.