13255-48-6Relevant articles and documents
Synthesis of di- and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues
Fusari, Matteo,Fallarini, Silvia,Lombardi, Grazia,Lay, Luigi
, p. 7439 - 7447 (2015)
Zwitterionic polysaccharides (ZPS) behave like traditional T cell-dependent antigens, suggesting the design of new classes of vaccines alternative to currently used glycoconjugates and based on the artificial introduction of a zwitterionic charge motif onto the carbohydrate structure of pathogen antigens. Here we report the new synthesis and antigenic evaluation of di-/tri-saccharide fragments of Salmonella typhi Vi polysaccharide, as well as of their corresponding zwitterionic analogues. Our strategy is based on versatile intermediates enabling chain elongation either by iterative single monomer attachment or by faster and more flexible approach using disaccharide donors. The effect of structural modifications of the synthetic compounds on antigenic properties was evaluated by competitive ELISA. All the oligosaccharides were recognized by specific anti-Vi polyclonal antibodies in a concentration-dependent manner, and the introduction of a zwitterionic motif into the synthetic molecules did not prevent the binding.
A red ycin A derivatives, its preparation method, intermediate and application
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Paragraph 0101; 0102, (2016/10/10)
The invention discloses an erythrocin A derivative represented by a general formula I. R1 and R2 are independent H, C1-C6 alkyl, replaced or not replaced C6-C10 aryl, or replaced or not replaced C4-C8 miscellaneous aryl; or the R1 and R2 are connected to form (CH2)n, wherein n is from 2 to 7; the substituent group of the aryl or the miscellaneous aryl is one type or a plurality of types of halogen, nitro, R3R4N-, C1-C6 alkoxy, C1-C6 alkyl and C6-C10 aryl, the heteroatom of the miscellaneous aryl is S, O or N, the number of the heteroatom in the miscellaneous aryl is from one to three, and R3 and R4 are the independent C1-C6 alkyl. The invention further discloses a preparation method of the compound I, an intermediate and an application. The compound has high antimicrobial activity particularly to a G+ bacterium.