133-67-5 Usage
Description
Trichlormethiazide, a diuretic and antihypertensive agent, belongs to the benzothiadiazide class. It is a white or practically white, crystalline powder with a slight characteristic odor. It shares similar properties with Hydrochlorothiazide and is used for various medical applications due to its diuretic and blood pressure-lowering effects.
Uses
Used in Human Medicine:
Trichlormethiazide is used as a diuretic and antihypertensive agent for the treatment of edema, including conditions associated with heart failure, hepatic cirrhosis, and corticosteroid therapy. It is also used to manage hypertension in the United States, with the usual dose being 2 to 4 mg twice a day (approximately 0.033 to 0.066 mg/kg bw/day).
Used in Veterinary Medicine:
In the veterinary industry, Trichlormethiazide is employed as a diuretic and anti-hypertensive agent for cattle, sheep, goats, pigs, and horses. The therapeutic regimen involves a single intramuscular dose of 0.4 mg/kg bw, followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Originator
Naqua,Schering,US,1960
Manufacturing Process
A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9
grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was
heated at the boiling temperature and under reflux for 30 minutes. The
reaction mixture was thereafter poured into a mixture of ice and water to
precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro-
1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to
270°C with decomposition.
Therapeutic Function
Diuretic
Check Digit Verification of cas no
The CAS Registry Mumber 133-67-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 133-67:
(5*1)+(4*3)+(3*3)+(2*6)+(1*7)=45
45 % 10 = 5
So 133-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)