1330787-05-7

Basic information

• Product Name: 3-((2-chloro-4-fluorophenylamino)methyl)-5-fluoro-3-hydroxy-1-methylindolin-2-one
• CAS NO: 1330787-05-7
• Molecular Weight: 338.741
• Mol File: 1330787-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-((2-chloro-4-fluorophenylamino)methyl)-5-fluoro-3-hydroxy-1-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((2-chloro-4-fluorophenylamino)methyl)-5-fluoro-3-hydroxy-1-methylindolin-2-one(1330787-05-7)
• EPA Substance Registry System: 3-((2-chloro-4-fluorophenylamino)methyl)-5-fluoro-3-hydroxy-1-methylindolin-2-one(1330787-05-7)

Safety Data

• Hazardous Substances Data: 1330787-05-7(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 773-91-1 5-fluoro-1-methylisatin 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 1330786-78-1 5-fluoro-1-methylspiro[indoline-3,2'-oxiran]-2-one 
• 2106-02-7 2-chloro-4-fluoroaniline 

Relevant articles and documents

Regiospecific epoxide opening: A facile approach for the synthesis of 3-hydroxy-3-aminomethylindolin-2-one derivatives

A mild and eco-friendly method has been developed for aminolysis of 3-oxirane-indolin-2-ones with aliphatic and aromatic amines to afford 3-hydroxy-3-aminomethylindolin-2-ones. An enhancement in reaction rate was observed when water was used as the reaction medium. The reactions proceed regiospecifically to open the epoxide ring from the less-substituted end.