133117-48-3

Basic information

• Product Name: Silane, (2,6-difluorophenyl)trimethyl-
• Synonyms: .2,6-Difluorophenyltrimethylsilane;(2,6-difluorophenyl)trimethylsilane;.2,6-Difluorphenyl-trimethylsilan;.2,6-difluorophenyl-trimethylsilane
• CAS NO: 133117-48-3
• Molecular Formula: C9H12F2Si
• Molecular Weight: 186.277
• Mol File: 133117-48-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Silane, (2,6-difluorophenyl)trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (2,6-difluorophenyl)trimethyl-(133117-48-3)
• EPA Substance Registry System: Silane, (2,6-difluorophenyl)trimethyl-(133117-48-3)

Safety Data

• Hazardous Substances Data: 133117-48-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 372-18-9 1,3-Difluorobenzene 
• 754-05-2 ethenyltrimethylsilane 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 13670-99-0 2,6-difluoroacetophenone 
• 13697-89-7 2,6-difluoroiodobenzene 
• 133117-49-4 2,6-difluorobenzenesulfonate de sodium 
• 64248-56-2 1-bromo-2,6-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 19064-24-5 2,6-difluoro-1-nitrobenzene 
• 446-35-5 2,4-Difluoronitrobenzene 
• 186315-85-5 1,3-difluoro-4-nitro-2-(trimethylsilyl)benzene 
• 420-56-4 trimethylsilyl fluoride 
• 781-16-8 2,2',6,6'-tetrafluoro-1,1'-biphenyl 
• 80006-60-6 bis(2,6-difluorophenyl)mercury 

Relevant articles and documents

Deprotonative Silylation of Aromatic C-H Bonds Mediated by a Combination of Trifluoromethyltrialkylsilane and Fluoride

A method for the deprotonative silylation of aromatic C-H bonds has been developed using trifluoromethyltrimethylsilane (CF3SiMe3, Ruppert-Prakash reagent) and a catalytic amount of fluoride. In this reaction, CF3SiMe3 is considered to act as a base and a silicon electrophile. This process is highly tolerant to various functional groups on heteroarenes and benzenes. Furthermore, this method can be applied to the synthesis of trimethylsilyl group-containing analogs of TAC-101, which is a bioactive synthetic retinoid with selective affinity for retinoic acid receptor α (RAR-α) binding. We also report further transformations of the silylated products into useful derivatives.

Synthetic applications of fluorinated phenyllithiums: Preparation of fluorinated α-methylstyrenes, benzhydrols, benzophenones and aryltrimethylsilanes

Regioselective preparations of a number of fluorinated phenyllithiums have recently been reported, which in some cases also contain one or more bromine substituents. These have now been applied to the synthesis of the corresponding halogenated 2-arylpropenes (α-methyl-styrenes), benzhydrols, trifluoromethylbenzhydrols, benzophenones and aryltrimethylsilanes.