133216-45-2 Usage
Description
L-697818, also known as N-Des(1,1-dimethylethyl) N-Cyclohexyl Finasteride, is an impurity of Finasteride (F342000). Finasteride is an inhibitor of 5α-reductase, the enzyme responsible for converting testosterone to the more potent androgen 5α-dihydrotestosterone. L-697818 is also recognized as an antialopecia agent.
Uses
Used in Pharmaceutical Industry:
L-697818 is used as an impurity in Finasteride, which is a medication for treating benign prostatic hyperplasia (BPH) and male pattern hair loss. As an inhibitor of 5α-reductase, Finasteride helps reduce the levels of dihydrotestosterone (DHT), leading to decreased prostate size and improved hair growth in men with androgenetic alopecia.
Used in Hair Loss Treatment:
L-697818 is used as an antialopecia agent for promoting hair growth and preventing hair loss in individuals suffering from androgenetic alopecia. By inhibiting the 5α-reductase enzyme, it helps reduce DHT levels, which is believed to contribute to hair follicle miniaturization and hair loss.
Check Digit Verification of cas no
The CAS Registry Mumber 133216-45-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,2,1 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 133216-45:
(8*1)+(7*3)+(6*3)+(5*2)+(4*1)+(3*6)+(2*4)+(1*5)=92
92 % 10 = 2
So 133216-45-2 is a valid CAS Registry Number.
133216-45-2Relevant articles and documents
Impurities in finasteride: Identification, synthesis, characterization and control of potential carry-over impurities from reagents used for the process
Mohanty, Sandeep,Kumar, B. Pavan,Karmakar, Arun Chandra
, p. 4375 - 4380 (2014/08/05)
An assessment of the impurity profile of finasteride and possible carry-over related substances likely to arise during the synthesis of finasteride is described in this article. Impurities in reaction mass were monitored by HPLC, potential impurities isolated with preparative HPLC and structures were substantiated by 1H NMR, MS and MS-MS. Impurities RRT's were established by HPLC co-injection. Based on the spectral data structure of impurity I and impurity II were characterized as cyclohexyl and phenyl analog of finasteride.
