1332708-08-3

Basic information

• Product Name: C₂₇H₃₄N₆O
• CAS NO: 1332708-08-3
• Molecular Weight: 458.607
• Mol File: 1332708-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₄N₆O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₄N₆O(1332708-08-3)
• EPA Substance Registry System: C₂₇H₃₄N₆O(1332708-08-3)

Safety Data

• Hazardous Substances Data: 1332708-08-3(Hazardous Substances Data)

Upstream product

• 2972-52-3 2,4-dichloropyrimidine-5-carbonyl chloride 
• 3177-20-6 2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester 
• 1332708-03-8 C₂₀H₂₇N₅O₂ 
• 100-46-9 benzylamine 
• 1346708-80-2 C₂₁H₂₉N₅O₂ 
• 1332708-02-7 C₁₀H₁₄ClN₃O₂ 

Relevant articles and documents

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel

TrpA1 is an ion channel involved in nociceptive and inflammatory pain. It is implicated in the detection of chemical irritants through covalent binding to a cysteine-rich intracellular region of the protein. While performing an HTS of the Pfizer chemical collection, a class of pyrimidines emerged as a non-reactive, non-covalently binding family of agonists of the rat and human TrpA1 channel. Given the issues identified with the reference agonist Mustard Oil (MO) in screening, a new, non-covalently binding agonist was optimized and proved to be a superior agent to MO for screening purposes. Compound 16a (PF-4840154) is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse.