1334511-82-8

Basic information

• Product Name: C₄₅H₆₀N₄O₈
• Synonyms: C₄₅H₆₀N₄O₈
• CAS NO: 1334511-82-8
• Molecular Weight: 784.993
• Mol File: 1334511-82-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₅H₆₀N₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₅H₆₀N₄O₈(1334511-82-8)
• EPA Substance Registry System: C₄₅H₆₀N₄O₈(1334511-82-8)

Safety Data

• Hazardous Substances Data: 1334511-82-8(Hazardous Substances Data)

Upstream product

• 158937-30-5 4′′-pentyloxy-[1,1':4',1′′-terphenyl]-4-carboxylic acid methyl ester 
• 63619-51-2 4-bromo-4'-pentyloxybiphenyl 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 38017-75-3 N-tert-butoxycarbonyl-L-valyl-L-proline methyl ester 
• 29558-77-8 4-bromo-4'-hydroxybiphenyl 
• 110-53-2 1-Bromopentane 
• 158938-08-0 4′′-(pentyloxy)-1,1′:4′,1′′-terphenyl-4-carboxylic acid 
• 1334511-76-0 Nδ-Boc-Orn(Nα-Fmoc)-Val-Pro-OMe 
• 158937-25-8 4-(4-n-pentyloxyphenyl)phenylboronic acid 

Relevant articles and documents

Total synthesis and structure-activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

A series of new echinocandin-like cyclolipohexapeptides were designed and total synthesized via solution phase [3 + 3]-segment coupling strategy with an attempt to improve antifungal activity. The designed compounds showed potent antifungal activities with broad spectrum. In particular, 11 compounds (i.e. 28a-e, 28g, 28i-j, 29a, 29c and 29e) showed better in vitro antifungal activities against Candida albicans or Aspergillus fumigatus than caspofungin. Moreover, the synthesized compounds provided new SAR information for the echinocandins. The findings in this work suggested that the "left" tripeptide segment of cyclolipohexapeptide scaffold might be a hydrophilic structural motif, whereas the "right" lipopeptide segment was preferred as a hydrophobic core. The amino acid component of the cyclolipohexapeptide scaffold could significantly affect the SAR of the side chains.