13368-86-0Relevant articles and documents
VINYL DERIVATIVES OF HETEROCYCLIC SYSTEMS AND THEIR POLIMERS: 3-VINYL-1,2,5-THIADIAZOLE
Bertini, V.,Lucchesini, F.,Munno, A. de
, p. 1245 - 1248 (1980)
3-Vinyl-1,2,5-thiadiazole is prepared by different methods: by one-pot reaction from 1,2,5-thiadiazole, by cyclization of 3,4-diamino-1-butene, and by the Wittig procedure either from 1,2,5-thiadiazolylmethylenetriphenylphosphorane or from 3-formyl-1,2,5-thiadiazole.Some physical and chemical properties are described.
4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page 42, (2010/02/07)
3-Substituted pyrrolidines having a spiropiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
Preparation of 1,2,5-Thiadiazole-3-carboxaldehydes
Mataka, Shuntaro,Kurisu, Masayoshi,Takahashi, Kazufumi,Tashiro, Masashi
, p. 325 - 328 (2007/10/02)
1,2,5-Thiadiazole-3-carboxaldehydes 1a-c were prepared by the acid-catalyzed decomposition of 3-azidomethyl-1,2,5-thiadiazoles 2a-c in 68-83percent yields, respectively.Pyrolysis of 2a and 2b afforded the imidazoles 4a and 4b in low yields.NBS-bromination of 1a and 1b gave the corresponding carboxylic acids 10a and 10b via acid bromides 9.Azides 2a and 2b gave the s-triazines 8a and 8b on treatment with NBS.