133876-92-3

Basic information

• Product Name: Nattokinase
• Synonyms: Nattokinase;Nattoesse Haruno-Ogawa;4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
• CAS NO: 133876-92-3
• Molecular Formula: C20H23BCl2N2O9
• Molecular Weight: 517.12162
• Mol File: 133876-92-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Nattokinase(CAS DataBase Reference)
• NIST Chemistry Reference: Nattokinase(133876-92-3)
• EPA Substance Registry System: Nattokinase(133876-92-3)

Safety Data

• Hazardous Substances Data: 133876-92-3(Hazardous Substances Data)

Usage

Description

Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from boiled soybeans fermented with the bacterium Bacillus natto. This enzyme, known for its fibrinolytic and thrombolytic properties, has been the subject of various health claims, although clinical trials and substantial evidence are still limited.

Uses

Used in Pharmaceutical Industry:
Nattokinase is used as a fibrinolytic and thrombolytic agent for its potential ability to break down blood clots and improve circulation. However, clinical trials are lacking to support such use, and there is no substantial evidence that nattokinase lowers blood pressure in hypertension.
Used in Food Industry:
Nattokinase is derived from natto, a popular Japanese food, which is consumed for its unique taste and health benefits. The enzyme's presence in natto contributes to its appeal as a traditional fermented food with potential health-promoting properties.

Mechanism of action

Nattokinase decreases the ability of blood to clot. This "thins the blood" and might protect against conditions caused by blood clots such as stroke, heart attack, and others.

Side effects

Small, short-term trials evaluating nattokinase reported no adverse reactions. There is a theoretical risk of bleeding, based on a case report of acute cerebellar hemorrhage in a patient with a history of ischemic stroke. Thrombosis was reported after substitution of nattokinase for warfarin in a patient with a mechanical aortic valve. Rare cases of late-onset anaphylaxis with natto have been attributed to poly-gamma-glutamic acid, a product of the fermentation process that may be present in nattokinase supplements.