133882-79-8Relevant articles and documents
Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABAA Receptor Modulators
Sonar, Vijay P.,Fois, Benedetta,Distinto, Simona,Maccioni, Elias,Meleddu, Rita,Cottiglia, Filippo,Acquas, Elio,Kasture, Sanjay,Floris, Costantino,Colombo, Daniele,Sissi, Claudia,Sanna, Enrico,Talani, Giuseppe
, p. 1250 - 1257 (2019/05/10)
Nine compounds, including two undescribed withanolides, withasomniferolides A and B (1 and 2), three known withanolides (3-5), a ferulic acid dimeric ester (6), and an inseparable mixture of three long alkyl chain ferulic acid esters (7-9), were isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera. The structures of the isolated compounds were elucidated based on NMR, MS, and ECD data analysis. In order to bioassay the single ferulic acid derivatives, compounds 6-9 were also synthesized. The most active compound, docosanyl ferulate (9), was able to enhance the GABAA receptor inhibitory postsynaptic currents with an IC50 value of 7.9 μM. These results, by showing an ability to modulate the GABAA receptor function, cast fresh light on the biological activities of the secondary metabolites of W. somnifera roots.
Alkyl ferulates in wound healing potato tubers.
Bernards,Lewis
, p. 3409 - 3412 (2007/10/02)
Seven ferulic acid esters of 1-alkanols ranging in carbon length from C16 to C28 were synthesized and an HPLC protocol for their separation developed. Extracts prepared from wound healing potato (Solanum tuberosum) tubers and analysed by HPLC indicated th
