1338935-88-8

Basic information

• Product Name: 1,1,6-trimethyl-3,4-diphenyl-1H-isochromene
• Synonyms: 1,1,6-trimethyl-3,4-diphenyl-1H-isochromene
• CAS NO: 1338935-88-8
• Molecular Weight: 326.438
• Mol File: 1338935-88-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,1,6-trimethyl-3,4-diphenyl-1H-isochromene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,6-trimethyl-3,4-diphenyl-1H-isochromene(1338935-88-8)
• EPA Substance Registry System: 1,1,6-trimethyl-3,4-diphenyl-1H-isochromene(1338935-88-8)

Safety Data

• Hazardous Substances Data: 1338935-88-8(Hazardous Substances Data)

Upstream product

• 1197-01-9 p-cymene-8-ol 
• 1989-25-9 4-chlorocumyl alcohol 
• 501-65-5 diphenyl acetylene 
• 402-41-5 4-fluorocumyl alcohol 

Relevant articles and documents

The oxidative annulation of tertiary benzyl alcohols with internal alkynes using an (electron-deficient η5-cyclopenta-dienyl)rhodium(III) catalyst under ambient conditions

It has been established that a dinuclear (electron-deficient η5-cyclopentadienyl)rhodium(III) complex catalyzes the oxidative annulation of tertiary benzyl alcohols with internal alkynes via sp2 C-H/O-H functionalization under ambient conditions (at room temperature under air) to give substituted isochromenes in good yields. The preference for annulation across electron-rich substrates over electron-deficient substrates was observed using this electron-deficient rhodium(III) complex.

Synthesis of isochromene and related derivatives by rhodium-catalyzed oxidative coupling of benzyl and allyl alcohols with alkynes

The straightforward synthesis of isochromene derivatives and related cyclic ethers is achieved by the rhodium-catalyzed oxidative coupling of α,α-disubstituted benzyl and allyl alcohols with alkynes. The hydroxy groups effectively act as the key function for the regioselective C-H bond cleavage.