134390-45-7

Basic information

• Product Name: 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester
• Synonyms: 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester
• CAS NO: 134390-45-7
• Molecular Weight: 224.213
• Mol File: 134390-45-7.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester(134390-45-7)
• EPA Substance Registry System: 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester(134390-45-7)

Safety Data

• Hazardous Substances Data: 134390-45-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 18632-39-8 ethyl 2-hydroxy-3-phenyl-3-oxopropanoate 
• 176504-79-3 ethyl (2E)-3-diethylamino-3-phenylprop-2-enoate 
• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 98-95-3 nitrobenzene 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 121-39-1 ethyl 3-phenylglycidate 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 3885-45-8 ethyl 2,3-dioxo-3-phenylpropanoate 
• 75-05-8 acetonitrile 
• 628-20-6 4-Chlorobutyronitrile 

Relevant articles and documents

Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement

An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed.

Aerobic oxidation of β-dicarbonyls into vicinal tricarbonyls by Cu(II) salts for one-pot synthesis of quinoxalines

Vicinal tricarbonyl intermediates are directly synthesized from β-dicarbonyls with the aid of Cu(II) salts and air, and they are further condensed with phenylene diamine to produce a range of quinoxalines in moderate to good yields in one-pot reaction.

Structural insights into the desymmetrization of bulky 1,2-dicarbonyls through enzymatic monoreduction

Benzil reductases are dehydrogenases preferentially active on aromatic 1,2-diketones, but the reasons for this peculiar substrate recognition have not yet been clarified. The benzil reductase (KRED1-Pglu) from the non-conventional yeast Pichia glucozyma showed excellent activity and stereoselectivity in the monoreduction of space-demanding aromatic 1,2-dicarbonyls, making this enzyme attractive as biocatalyst in organic chemistry. Structural insights into the stereoselective monoreduction of 1,2-diketones catalyzed by KRED1-Pglu were investigated starting from its 1.77 ? resolution crystal structure, followed by QM and classical calculations; this study allowed for the identification and characterization of the KRED1-Pglu reactive site. Once identified the recognition elements involved in the stereoselective desymmetrization of bulky 1,2-dicarbonyls mediated by KRED1-Pglu, a mechanism was proposed together with an in silico prediction of substrates reactivity.

Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles

An efficient organocatalytic atroposelective three-component cascade reaction of 2,3-diketoesters, aromatic amines, and 1,3-cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N-arylindoles. The success of this method derives from the use of a newly developed second-generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand.