1346133-39-8Relevant articles and documents
Method for preparing erdafitinib
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, (2021/06/26)
The invention provides a method for preparing erdafitinib. According to the method disclosed by the invention, the reaction step number is only four, and the yield of a halogenation reaction product is high. The synthetic route provided by the invention n
Sodium Butylated Hydroxytoluene: A Functional Group Tolerant, Eco-Friendly Base for Solvent-Free, Pd-Catalysed Amination
Semeniuchenko, Volodymyr,Braje, Wilfried M.,Organ, Michael G.
supporting information, p. 12535 - 12539 (2021/08/03)
NaBHT (sodium 2,6-di-tert-butyl-4-methylphenolate), a strong, but hindered and lipophilic base, has been effectively paired with similarly lipophilic, high-reactivity Pd-NHC (N-heterocyclic carbene) catalysts to produce an ideal combination for performing
Preparation method of Erdafitinib intermediate
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, (2020/12/31)
The invention discloses a preparation method of an Erdafitinib intermediate 3-(1-methyl-1H-pyrazole-4-yl)-6-quinoxaline amine. The method comprises the steps of by using 2, 4-dinitroaniline as an initial raw material, sequentially carrying out condensation, reduction, cyclization and other basic unit reactions to obtain the target intermediate. The preparation process has the advantages of easilyavailable raw materials, rapidness, convenience, economy and environmental protection, is suitable for large-scale production, and provides a new preparation way for industrialization of Erdafitinib.