1346672-71-6

Basic information

• Product Name: (2-bromo-6-{4,4-dimethyl-9-oxo-7-thia-10-azatricyclo[6.4.0.02,6]dodeca-1⁽⁸⁾,2⁽⁶⁾-dien-10-yl}phenyl)methyl acetate
• Synonyms: (2-bromo-6-{4,4-dimethyl-9-oxo-7-thia-10-azatricyclo[6.4.0.02,6]dodeca-1⁽⁸⁾,2⁽⁶⁾-dien-10-yl}phenyl)methyl acetate
• CAS NO: 1346672-71-6
• Molecular Weight: 448.381
• Mol File: 1346672-71-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-bromo-6-{4,4-dimethyl-9-oxo-7-thia-10-azatricyclo[6.4.0.02,6]dodeca-1⁽⁸⁾,2⁽⁶⁾-dien-10-yl}phenyl)methyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-6-{4,4-dimethyl-9-oxo-7-thia-10-azatricyclo[6.4.0.02,6]dodeca-1⁽⁸⁾,2⁽⁶⁾-dien-10-yl}phenyl)methyl acetate(1346672-71-6)
• EPA Substance Registry System: (2-bromo-6-{4,4-dimethyl-9-oxo-7-thia-10-azatricyclo[6.4.0.02,6]dodeca-1⁽⁸⁾,2⁽⁶⁾-dien-10-yl}phenyl)methyl acetate(1346672-71-6)

Safety Data

• Hazardous Substances Data: 1346672-71-6(Hazardous Substances Data)

Upstream product

• 69321-60-4 2,6-dibromotoluene 
• 20500-49-6 3,3-dimethylcyclopentanone 
• 2758-18-1 3-Methyl-2-cyclopenten-1-one 
• 93701-32-7 2,6-dibromobenzyl bromide 
• 1147858-83-0 acetic acid 2,6-dibromobenzyl ester 
• 1346672-70-5 6,6-dimethyl-3,4,6,7-tetrahydro-5H-cyclopenta[4,5]thieno[2,3-c]pyridine-1(2H)-one 
• 1346672-63-6 2-chloro-4,4- dimethylcyclopent-1-ene-1-carbaldehyde 
• 1346672-62-5 ethyl 5,5-dimethyl-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate 
• 1346672-64-7 5,5-dimethyl-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylic Acid 
• 1346672-66-9 C₁₀H₁₁ClOS 
• 1346672-65-8 N-methoxy-N,5,5-trimethyl-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide 
• 1346672-67-0 3-chloro-1-(5,5-dimethyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)propan-1-one 
• 1346672-68-1 10,10-dimethyl-7-thiatricyclo[6.3.0.0[2,6]]undeca-1⁽⁸⁾,2⁽⁶⁾-dien-5-one 
• 1346672-69-2 6,6-dimethyl-1,2,6,7-tetrahydrodicyclopenta[b,d]thiophen-3(5H)-one oxime 

Downstream Products

• 1346673-28-6 C₂₇H₃₄BNO₅S 
• 1346669-80-4 5-(3-(6,6-dimethyl-3,4,6,7-tetrahydro-5H-cyclopenta[4,5]thieno[2,3-c]pyridine-1(2H)-yl)-2-(hydroxymethyl)phenyl)-1-methyl-3-(1-ethyl-1H-pyrazol-4-ylamino)pyrazin-2(1H)-one 

Relevant articles and documents

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

In our continued effort to discover and develop best-in-class Bruton's tyrosine kinase (Btk) inhibitors for the treatment of B-cell lymphomas, rheumatoid arthritis, and systemic lupus erythematosus, we devised a series of novel tricyclic compounds that improved upon the druglike properties of our previous chemical matter. Compounds exemplified by G-744 are highly potent, selective for Btk, metabolically stable, well tolerated, and efficacious in an animal model of arthritis.