1350844-81-3

Basic information

• Product Name: 3-(4-chlorophenyl)-1-methylisoquinoline
• Synonyms: 3-(4-chlorophenyl)-1-methylisoquinoline
• CAS NO: 1350844-81-3
• Molecular Weight: 253.731
• Mol File: 1350844-81-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-1-methylisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-1-methylisoquinoline(1350844-81-3)
• EPA Substance Registry System: 3-(4-chlorophenyl)-1-methylisoquinoline(1350844-81-3)

Safety Data

• Hazardous Substances Data: 1350844-81-3(Hazardous Substances Data)

Upstream product

• 1350843-85-4 1-(2-((4-chlorophenyl)ethynyl)phenyl)ethan-1-one 
• 1956-39-4 4-chloroacetophenone oxime 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 208118-80-3 1-(4-chlorophenyl)ethenylacetamide 
• 1402452-42-9 3-(4-chlorophenyl)isoquinoline 2-oxide 
• 67-68-5 dimethyl sulfoxide 
• 1286747-86-1 C₁₅H₁₀ClNO 
• 6630-33-7 ortho-bromobenzaldehyde 
• 22479-32-9 1-(4-chlorophenyl)vinyl acetate 
• 19433-17-1 (E)‐1‐phenylethan‐1‐one O‐acetyl oxime 
• 873-73-4 4-n-chlorophenylacetylene 
• 19848-64-7 (E)-2-(2-(1-phenylethylidene)hydrazineyl)pyridine 
• 28153-25-5 1-Phenyl-1-ethanon-acetylhydrazon 
• 1354970-09-4 1-(1-azido-2-iodoethyl)-4-chlorobenzene 

Relevant articles and documents

Rh-catalyzed sequential oxidative C-H activation/annulation with geminal-substituted vinyl acetates to access isoquinolines

The concise synthesis of 3-substituted or non-C3-substituted isoquinolines through Rh-catalyzed sequential oxidative C-H activation/annulation with geminal-substituted vinyl acetates was developed with good functional group tolerance. The protocol was successfully applied to the total synthesis of the natural product papaverine.

Synthesis method of 1, 3-disubstituted isoquinoline derivative

The invention discloses a synthesis method of a 1, 3-disubstituted isoquinoline derivative, which comprises the steps of adding an enamine compound, a sulfoxide ylide compound and a dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer into an organic solvent, heating under a nitrogen condition to react, and after the reaction is completed, performing post-treatment to obtain the 1, 3-disubstituted isoquinoline compound. According to the method, the 1, 3-disubstituted isoquinoline derivative is synthesized in one step through simple and easily available raw materials, the conversion efficiency is high, and the atom economy is good; and meanwhile, the method is simple to operate, high in reaction yield and wide in substrate adaptability.

Bidentate Directing-Enabled, Traceless Heterocycle Synthesis: Cobalt-Catalyzed Access to Isoquinolines

Traceless heterocycle synthesis based on transition-metal-catalyzed C-H functionalization is synthetically appealing but has been realized only in monodentate directing systems. Bidentate directing systems allow for the achievement of high catalytic reactivity without the need for a high-cost privileged ligand. The first bidentate directing-enabled, traceless heterocycle synthesis is demonstrated in the cobalt-catalyzed synthesis of isoquinolines via 2-hydrazinylpyridine-directed C-H coupling/cyclization with alkynes. Convenient directing group installation through a ubiquitously present ketone group allows synthetic elaboration for complex molecules.