1352131-48-6Relevant articles and documents
Continuous circulation industrial production method of 5-tert-butyl-5-hydroxy-1, 3-diphenyl-2, 4-imidazolinedione
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Paragraph 0045-0065, (2021/04/21)
The invention belongs to the technical field of intermediate preparation, and particularly relates to a continuous circulation industrial production method of 5-tert-butyl-5-hydroxy-1, 3-diphenyl-2, 4-imidazolinedione. The method comprises the following steps: heating an initiator, a solvent and magnesium chips to 65-75 DEG C, dropwise adding tert-butyl chloride to prepare a Grignard reagent, then conveying the Grignard reagent to a Grignard reaction kettle, carrying out a synthetic reaction on the Grignard reagent and 1, 3-diphenyl-2, 4, 5-imidazolintrione, transferring a reaction solution generated by the reaction to a quenching kettle containing diluted hydrochloric acid for quenching, separating the solution after the reaction is finished, and preparing 5-tert-butyl-5-hydroxy-1, 3-diphenyl-2, 4-imidazolidinone According to the industrial production method disclosed by the invention, the amplification production of the tert-butyl Grignard reagent is creatively realized, so that the industrial continuous production of the 5-tert-butyl-5-hydroxy-1, 3-diphenyl-2, 4-imidazoline diketone is realized, and the purity and the yield of the prepared product are high.
