1352642-02-4

Basic information

• Product Name: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate
• CAS NO: 1352642-02-4
• Molecular Weight: 291.304
• Mol File: 1352642-02-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate(1352642-02-4)
• EPA Substance Registry System: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate(1352642-02-4)

Safety Data

• Hazardous Substances Data: 1352642-02-4(Hazardous Substances Data)

Upstream product

• 74124-79-1 di(succinimido) carbonate 
• 1263166-90-0 (1R,8S,9S)‐bicyclo[6.1.0]non‐4‐yn‐9‐ylmethanol 
• 1552-12-1 1,5-cis,cis-cyclooctadiene 

Relevant articles and documents

VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES

The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate having structure (1): Formula (1) wherein: - a, b and c are each independently 0 or 1; - L1, L2 and L3 are linkers; - D is a payload; - BM is a branching moiety; - Z are connecting groups obtainable by a cycloaddition reaction. The invention further provides a method for preparing the antibody-payload conjugate according to the invention, an intermediate compound in that preparation method, and medical uses of the antibody-payload conjugate according to the invention.

VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES

The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate is according to structure (1): formula (1), wherein: - a, b, c and d are each independently 0 or 1; - e is an integer in the

MOLECULAR LOGIC GATES FOR CONTROLLED MATERIAL DEGRADATION

The present disclosure features, inter alia, a cyclic multifunctional linker, including at least two cleavable moieties; at least two connecting chains connected to the at least two cleavable moieties to provide a cyclic structure; and at least two linkin