1353634-71-5Relevant articles and documents
A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles
Yavari, Issa,Khaledian, Omid
, p. 9150 - 9153 (2020/10/02)
N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is
Tri- and tetrasubstituted pyrazole derivates: Regioisomerism switches activity from p38MAP kinase to important cancer kinases
Thaher, Bassam Abu,Arnsmann, Martina,Totzke, Frank,Ehlert, Jan E.,Kubbutat, Michael H. G.,Sch?chtele, Christoph,Zimmermann, Markus O.,Koch, Pierre,Boeckler, Frank M.,Laufer, Stefan A.
supporting information; experimental part, p. 961 - 965 (2012/03/10)
In the course of searching for new p38α MAP kinase inhibitors, we found that the regioisomeric switch from 3-(4-fluorophenyl)-4-(pyridin-4-yl)-1- (aryl)-1H-pyrazol-5-amine to 4-(4-fluorophenyl)-3-(pyridin-4-yl)-1-(aryl)-1H- pyrazol-5-amine led to an almos